6.1.1.27: O-phospho-L-serine-tRNA ligase
This is an abbreviated version!
For detailed information about O-phospho-L-serine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.27
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6.1.1.27
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cys-trnacys
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methanogen
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aminoacylation
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archaea
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sepcyss
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cysteinyl-trna
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sep-trna:cys-trna
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o-phosphoserine
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anticodons
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aminoacyl-trnas
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maripaludis
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trna-dependent
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cysteinyl-trnacys
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selenocysteine
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methanocaldococcus
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jannaschii
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phosphoserylation
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pylrs
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aarss
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faithful
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mazei
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methanosarcina
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gca
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alpha4
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web-based
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biologists
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phenylalanyl-trna
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asnrs
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ilers
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biotechnology
- 6.1.1.27
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cys-trnacys
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methanogen
- aminoacylation
- archaea
- sepcyss
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cysteinyl-trna
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sep-trna:cys-trna
- o-phosphoserine
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anticodons
- aminoacyl-trnas
- maripaludis
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trna-dependent
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cysteinyl-trnacys
- selenocysteine
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methanocaldococcus
- jannaschii
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phosphoserylation
- pylrs
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aarss
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faithful
- mazei
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methanosarcina
- gca
-
alpha4
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web-based
-
biologists
- phenylalanyl-trna
- asnrs
- ilers
- biotechnology
Reaction
Synonyms
CysRS, Cysteinyl-tRNA synthetase, More, O-phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetases, SepRS, sepS
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 6.1.1.27 - O-phospho-L-serine-tRNA ligase
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REACTION DIAGRAM
AMP + diphosphate + O-phospho-L-serine-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-serine-tRNACys
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AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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phosphoseryl-tRNA synthetase is a natural non-standard aminoacyl-tRNA synthetase, which charges a non-standard amino acid, phosphoserine, to tRNACys containing a GCA anticodon for tRNA-dependent cysteine biosynthesis in some archaea
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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Methanocaldococcus jannaschii synthesizes Cys-tRNACys by an indirect pathway, whereby O-phosphoseryltRNA synthetase (SepRS) acylates tRNACys with phosphoserine (Sep), and Sep-tRNACys-tRNA synthase (SepCysS) converts the tRNA-bound phosphoserine to cysteine
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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Methanococcus maripaludis encodes both the direct and indirect paths for Cys-tRNACys synthesis. SepS (encoding SepRS) can be deleted when the organism is grown in the presence of Cys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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the enzyme charges tRNACys with a 3'-deoxyadenosine, but not tRNACys without A76 or with a 2'-deoxyadensosine
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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half-of-the-sites activity: the tetrameric enzyme binds two tRNAs. Only two of the four chemically equivalent subunits catalyze formation of phosphoseryl adenylate
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ATP + O-phospho-L-serine + tRNACys
AMP + diphosphate + O-phospho-L-seryl-tRNACys
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some methanogenic archaea synthesize Cys-tRNACys needed for protein synthesis using both a canonical cysteinyl-tRNA synthetase as well as a set of two enzymes that operate via a separate indirect pathway. In the indirect route, Sep-tRNACys is first synthesized by SepRS, and this misacylated intermediate is then converted to Cys-tRNACys by Sep-tRNA:Cys-tRNA synthase via a pyridoxal phosphate-dependent mechanism, structural basis for the tRNACys isoacceptor preferences of SepRS and CysRS, detailed overview
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two-step Cys-tRNACys formation: in organisms like Archaeoglobus fulgidus lacking a canonical cysteinyl-tRNA synthetase for the direct Cys-tRNACys formation, Cys-tRNACys is produced by the indirect pathway, in which the noncanonical O-phosphoseryl-tRNA synthetase, SepRS, ligates the noncanonical amino acid O-phosphoserine, Sep, to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, overview, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism
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additional information
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two-step Cys-tRNACys formation: in organisms like Methanococcus jannaschii lacking a canonical cysteinyl-tRNA synthetase for the direct Cys-tRNACys formation, Cys-tRNACys is produced by the indirect pathway, in which the noncanonical O-phosphoseryl-tRNA synthetase, SepRS, ligates the noncanonical amino acid O-phosphoserine, Sep, to tRNACys, and the Sep-tRNA:Cys-tRNA synthase converts the produced Sep-tRNACys to Cys-tRNACys, overview, the SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism
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additional information
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Methanocaldococcus jannaschii synthesizes Cys-tRNACys by an indirect pathway, whereby O-phosphoseryl-tRNA synthetase acylates tRNACys with phosphoserine, and Sep-tRNA-Cys-tRNA synthase converts the tRNA-bound phosphoserine to cysteine. Methanocaldococcus jannaschii SepRS differs from CysRS by recruiting the m1G37 modification as a determinant for aminoacylation
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