6.1.1.14: glycine-tRNA ligase

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For detailed information about glycine-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.14

6.1.1.14

cord

glycinergic

postsynaptic

strychnine

alpha1

synthetases

synapses

ligand-gated

aminoacyl-trna

homomeric

gabaars

neurotransmission

electrophysiological

aminoacylation

charcot-marie-tooth

strychnine-sensitive

gephyrin

patch-clamp

hyperekplexia

presynaptic

heteromeric

startle

pentameric

gabaergic

extrasynaptic

picrotoxin

glycylation

glycine-induced

single-channel

glycine-activated

cys-loop

anticodon

mipscs

subunit-specific

bicuculline

glycine-gated

outside-out

subunit-containing

alars

two-electrode

alpha2beta

mesolimbic

pore-lining

hisrs

glycine-mediated

accumbal

gabaar-mediated

molecular biology

medicine

Reaction

Synonyms

GARS, Glycine--tRNA ligase, Glycyl translase, glycyl tRNA synthetase, Glycyl-transfer ribonucleate synthetase, Glycyl-transfer ribonucleic acid synthetase, Glycyl-transfer RNA synthetase, Glycyl-tRNA synthetase, glycyl-tRNA synthetase 1, GlyRS, GlyRS1, GlyRS2, GRS1, More, Synthetase, glycyl-transfer ribonucleate

ECTree

6 Ligases

6.1 Forming carbon-oxygen bonds

6.1.1 Ligases forming aminoacyl-tRNA and related compounds

6.1.1.14 glycine-tRNA ligase

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Results	in table
72812	AA Sequence
4	Application
1	CAS Registry Number
28	Cloned(Commentary)
30	Cofactor
7	Crystallization (Commentary)
196	Disease/ Diagnostics
6	General Information
9	General Stability
23	Inhibitors
3	kcat/KM [mM/s]
4	Ki Value [mM]
59	KM Value [mM]
38	Localization
32	Metals/Ions
35	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
109	Organism
2	Pathway
44	PDB ID
12	pH Optimum
1	Posttranslational Modification
71	Protein Variants
21	Purification (Commentary)
2	Reaction
26	Reaction Type
96	Reference
1	Renatured (Commentary)
28	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
179	Substrates and Products (Substrate)
37	Subunits
157	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
3	Temperature Stability [°C]
9	Turnover Number [1/s]

General Information

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General Information on EC 6.1.1.14 - glycine-tRNA ligase

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malfunction

4 entries

metabolism

Homo sapiens

P41250

the essential enzyme for protein synthesis also plays a critical role in neddylation by specifically binding to NEDD8 and enhancing neddylation. The enzyme preferentially binds and protects Ubc12N8 and E, and regulates cell cycle progression

745876

physiological function

Homo sapiens

glycyl-tRNA synthetase specifically binds to the poliovirus internal ribosome entry site to activate translation initiation

728398