5.4.99.63: ethylmalonyl-CoA mutase
This is an abbreviated version!
For detailed information about ethylmalonyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.63
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5.4.99.63
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b12-dependent
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methylotrophic
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ethylamine
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glyoxylate
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isobutyryl-coa
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methylobacterium
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succinate
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extorquens
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assimilatory
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2r-methylmalonyl-coa
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mutases
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methylmalonyl-coa
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acyl-coa
- 5.4.99.63
-
b12-dependent
-
methylotrophic
- ethylamine
- glyoxylate
- isobutyryl-coa
-
methylobacterium
- succinate
- extorquens
-
assimilatory
-
2r-methylmalonyl-coa
- mutases
- methylmalonyl-coa
- acyl-coa
Reaction
Synonyms
Ecm, ethylmalonyl coenzyme A mutase, ethylmalonyl-CoA mutase, meaA
ECTree
5.4.99.63 ethylmalonyl-CoA mutaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 5.4.99.63 - ethylmalonyl-CoA mutase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-2-methylmalonyl-CoA
succinyl-CoA
0.2% of the activity with (2R)-ethylmalonyl-CoA
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-
?
(2R)-ethylmalonyl-CoA
(2S)-methylsuccinyl-CoA
purified recombinant Ecm is unable to form methylsuccinyl-CoA from ethylmalonyl-CoA when ethylmalonyl-CoA is produced by reductive carboxylation of crotonyl-CoA carboxylase/reductase. Addition of cell extract of the gene insertion mutant ecm::kan to the enzyme assay restores ethylmalonyl-CoA mutase activity due to presence of ethylmalonyl-CoA epimerase
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-
?
(2R)-ethylmalonyl-CoA
(2S)-methylsuccinyl-CoA
a reversible enzyme
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r
(2R)-ethylmalonyl-CoA
(2S)-methylsuccinyl-CoA
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
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-
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r
(2R)-ethylmalonyl-CoA
(2S)-methylsuccinyl-CoA
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
a reversible enzyme
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-
r
additional information
?
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enzyme catalyzes the transformation of ethylmalonyl-CoA to methylsuccinyl-CoA in combination with ethylmalonyl-CoA racemase in a ethylmalonyl-CoA dependent acyl-CoA pathway for acetate assimilation
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?
additional information
?
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enzyme catalyzes the transformation of ethylmalonyl-CoA to methylsuccinyl-CoA in combination with ethylmalonyl-CoA racemase in a ethylmalonyl-CoA dependent acyl-CoA pathway for acetate assimilation
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?
