5.4.99.63: ethylmalonyl-CoA mutase
This is an abbreviated version!
For detailed information about ethylmalonyl-CoA mutase, go to the full flat file.
Word Map on EC 5.4.99.63
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5.4.99.63
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b12-dependent
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methylotrophic
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ethylamine
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glyoxylate
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isobutyryl-coa
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methylobacterium
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succinate
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extorquens
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assimilatory
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2r-methylmalonyl-coa
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mutases
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methylmalonyl-coa
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acyl-coa
- 5.4.99.63
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b12-dependent
-
methylotrophic
- ethylamine
- glyoxylate
- isobutyryl-coa
-
methylobacterium
- succinate
- extorquens
-
assimilatory
-
2r-methylmalonyl-coa
- mutases
- methylmalonyl-coa
- acyl-coa
Reaction
Synonyms
Ecm, ethylmalonyl coenzyme A mutase, ethylmalonyl-CoA mutase, meaA
ECTree
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General Information
General Information on EC 5.4.99.63 - ethylmalonyl-CoA mutase
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malfunction
metabolism
physiological function
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intracellular ethylmalonyl-CoA concentration is increase by the deletion of the meaA gene encoding coenzyme B12-dependent ethylmalonyl-CoA mutase in combination with ethylmalonate supplementation
malfunction
overexpression of gene ecm removes control in the ethylmalonyl-CoA pathway
malfunction
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
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overexpression of gene ecm removes control in the ethylmalonyl-CoA pathway
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the metabolism of one- and two-carbon compounds by the methylotrophic bacterium Methylobacterium extorquens AM1 involves high carbon flux through the ethylmalonyl-CoA pathway (EMC pathway), metabolic pathway for two carbon metabolism, overview. During growth on ethylamine, the EMC pathway operates as a linear pathway carrying the full assimilatory flux to produce glyoxylate, malate, and succinate, metabolite profiles. Assimilatory carbon enters the ethylmalonyl-CoA pathway directly as acetyl-CoA, bypassing pathways for formaldehyde oxidation/assimilation and the regulatory mechanisms controlling them
metabolism
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
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the metabolism of one- and two-carbon compounds by the methylotrophic bacterium Methylobacterium extorquens AM1 involves high carbon flux through the ethylmalonyl-CoA pathway (EMC pathway), metabolic pathway for two carbon metabolism, overview. During growth on ethylamine, the EMC pathway operates as a linear pathway carrying the full assimilatory flux to produce glyoxylate, malate, and succinate, metabolite profiles. Assimilatory carbon enters the ethylmalonyl-CoA pathway directly as acetyl-CoA, bypassing pathways for formaldehyde oxidation/assimilation and the regulatory mechanisms controlling them
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the ethylmalonyl-CoA pathway, ethylmalonyl-CoA mutase is a metabolic control point to restrict the production of glyoxylate
physiological function
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
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the ethylmalonyl-CoA pathway, ethylmalonyl-CoA mutase is a metabolic control point to restrict the production of glyoxylate
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