5.4.4.6: 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

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For detailed information about 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, go to the full flat file.

Reaction

(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate

Synonyms

7,8-diol synthase, 7,8-LDS, 7,8-linoleate diol synthase, EC 1.13.11.44

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.4 Transferring hydroxy groups

5.4.4.6 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

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Results	in table
3	Activating Compound
5	AA Sequence
5	Cloned(Commentary)
3	Cofactor
3	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
1	Metals/Ions
3	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
22	Organism
1	Pathway
4	pH Optimum
1	pH Stability
1	pI Value
2	Posttranslational Modification
29	Protein Variants
5	Purification (Commentary)
1	Reaction
16	Reference
7	Source Tissue
4	Specific Activity [micromol/min/mg]
32	Substrates and Products (Substrate)
6	Subunits
16	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
4	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.4.4.6 - 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase

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(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate hydroxymutase [(7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate-forming]

The enzyme contains heme. The bifunctional enzyme from Gaeumannomyces graminis catalyses the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60, linoleate 8R-lipoxygenase), which is then isomerized to (7S,8S,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate [3].