5.4.2.7: phosphopentomutase

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For detailed information about phosphopentomutase, go to the full flat file.

Reaction

Synonyms

alpha-D-Glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase, alpha-D-ribose1,5-phosphomutase, deoB, Deoxyribomutase, Deoxyribose phosphomutase, EC 2.7.5.6, PGM3, Phosphodeoxyribomutase, Phosphomutase, deoxyribose, phosphopentomutase, Phosphoribomutase, PPM, PPMase

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.2 Phosphotransferases (phosphomutases)

                5.4.2.7 phosphopentomutase

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Results	in table
16	Activating Compound
14301	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
4	Crystallization (Commentary)
3	General Information
3	General Stability
8	Inhibitors
2	kcat/KM [mM/s]
13	KM Value [mM]
20	Metals/Ions
15	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
30	Organism
7	Pathway
64	PDB ID
8	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
4	Posttranslational Modification
8	Protein Variants
11	Purification (Commentary)
1	Reaction
5	Reaction Type
29	Reference
2	Source Tissue
10	Specific Activity [micromol/min/mg]
1	Storage Stability
59	Substrates and Products (Substrate)
19	Subunits
29	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]
4	Turnover Number [1/s]

Engineering

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Engineering on EC 5.4.2.7 - phosphopentomutase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D156A

Bacillus cereus

Q818Z9

site-directed mutagenesis, the D156A variant displays a dramatically reduced level of phosphorylation of the active site Thr85 compared to the wild-type, and does not acquire phosphatase activity

726977

K240A

Bacillus cereus

Q818Z9

site-directed mutagenesis, the K240A variant can be phosphorylated by the small molecule activator glucose 1,6-bisphosphate like the wild-type enzyme

726977

T85E

Bacillus cereus

Q818Z9

site-directed mutagenesis, the T85E variant mimics the active site charge of the activated state of the enzyme, the affinity for activator glucose 1,6-bisphosphate is 4.5fold reduced compared to the wild-type enzyme

726977

T85Q

Bacillus cereus

Q818Z9

site-directed mutagenesis, the T85Q variant mimics the active site charge of the unactivated state of the enzyme, the affinity for activator glucose 1,6-bisphosphate is only slightly reduced compared to the wild-type enzyme

726977

D156A

Bacillus cereus DSM 31

-

site-directed mutagenesis, the D156A variant displays a dramatically reduced level of phosphorylation of the active site Thr85 compared to the wild-type, and does not acquire phosphatase activity

-

K240A

Bacillus cereus DSM 31

-

site-directed mutagenesis, the K240A variant can be phosphorylated by the small molecule activator glucose 1,6-bisphosphate like the wild-type enzyme

-

T85E

Bacillus cereus DSM 31

-

site-directed mutagenesis, the T85E variant mimics the active site charge of the activated state of the enzyme, the affinity for activator glucose 1,6-bisphosphate is 4.5fold reduced compared to the wild-type enzyme

-

T85Q

Bacillus cereus DSM 31

-

site-directed mutagenesis, the T85Q variant mimics the active site charge of the unactivated state of the enzyme, the affinity for activator glucose 1,6-bisphosphate is only slightly reduced compared to the wild-type enzyme

-