5.4.2.6: beta-Phosphoglucomutase
This is an abbreviated version!
For detailed information about beta-Phosphoglucomutase, go to the full flat file.
Word Map on EC 5.4.2.6
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5.4.2.6
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1-phosphate
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lactis
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maltose
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phosphorane
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dehalogenase
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trehalose
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1,6-bisphosphate
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haloacid
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lactococci
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alpha-glucose
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analysis
- 5.4.2.6
- 1-phosphate
- lactis
- maltose
-
phosphorane
-
dehalogenase
- trehalose
- 1,6-bisphosphate
-
haloacid
-
lactococci
- alpha-glucose
- analysis
Reaction
Synonyms
beta-PGM, beta-phosphoglucomutase, betaPGM, PgcM, Phosphomutase, beta-glucose, PsPGM, Py04_1503, TM1254, YcjU
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Reaction
Reaction on EC 5.4.2.6 - beta-Phosphoglucomutase
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beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate
a single Mg2+ coordination site accomodates water, phosphate, and the phosphorane intermediate during catalytic turnover. Bi-bi ping-pong mechanism, substrate induced-fit mechanism allows phosphomutase activity to dominate over the intrinsic phosphatase activity
beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate
mechanism is a nucleophilic substitution via an associative pathway, enzyme stablizes the phosphorane intermediate along that pathway
beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate
phosphoryl transfer rather than ligand binding is rate-limiting. Beta-D-glucose 1,6-bisphosphate is a reaction intermediate and binds to the active site in two different orientations with roughly the same efficiency. Reorientation of the beta-D-glucose 1,6-bisphosphate intermediate occurs by diffusion into solvent followed by binding in the opposite orientation
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beta-D-Glucose 1-phosphate = beta-D-glucose 6-phosphate
reaction mechanism of the phosphoryl transfer starting from the bisphosphate intermediate beta-D-glucose-1,6-(bis)phosphate in both directions of the reversible reaction, overview. The calculated energy barrier of the reaction for the beta-D-glucose 1-phosphate to beta-D-glucose 1,6-diphosphate step is only slightly higher than for the beta-G1,6diP to beta-G6P step. Residues Ser114 and Lys145 and Mg2+ play important roles in stabilizing the large negative charge on the phosphate through strong coordination with the phosphate oxygens and guiding the phosphate group throughout the catalytic process
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