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5.4.2.6: beta-Phosphoglucomutase

This is an abbreviated version!
For detailed information about beta-Phosphoglucomutase, go to the full flat file.

Word Map on EC 5.4.2.6

Reaction

beta-D-glucose 1-phosphate
=
beta-D-glucose 6-phosphate

Synonyms

beta-PGM, beta-phosphoglucomutase, betaPGM, PgcM, Phosphomutase, beta-glucose, PsPGM, Py04_1503, TM1254, YcjU

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.2 Phosphotransferases (phosphomutases)
                5.4.2.6 beta-Phosphoglucomutase

Inhibitors

Inhibitors on EC 5.4.2.6 - beta-Phosphoglucomutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-D-galactose 1-phosphate
competitive
alpha-D-glucose 1-phosphate
-
10 mM, 12% inhibition
beta-D-glucose 1-phosphate
substrate inhibition is observed at concentrations of beta-D-glucose-1-phosphate greater than 0.2 mM
beta-D-glucose-1,6-bisphosphate
-
-
Ca2+
-
0.2 mM Ca2+ in presence of 0.5 mM Mn2+, 21% inhibition
CaCl2
-
1 mM, 77% inhibition
Co2+
-
0.2 mM Co2+ in presence of 0.5 mM Mn2+, 20% inhibition
D-fructose 1-6-diphosphate
-
10 mM, 63% inhibition
D-glucose 6-phosphate
-
10 mM, 11% inhibition
F-
formation of a MgF3- transition state analogue when glucose 6-phosphate, magnesium, and fluoride are present with the enzyme, in which MgF3- mimics the transferring PO3- moiety
fluoride
-
-
KF
-
10 mM: 75% inhibition, 17 mM: 100% inhibition
magnesium fluoride
-
time-dependent inhibition
Ni2+
-
0.2 mM Ni2+ in presence of 0.5 mM Mn2+, 29% inhibition
phosphate
-
10 mM, 20% inhibition
additional information
-
no inhibition by NEM and 5,5'-dithiobis(2-nitrobenzoate)
-