5.4.2.4: Bisphosphoglycerate mutase

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For detailed information about Bisphosphoglycerate mutase, go to the full flat file.

Reaction

Synonyms

2,3 bisphosphoglycerate mutase, 2,3-Bisphosphoglycerate mutase, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, 2,3-Diphosphoglycerate mutase, 2,3-Diphosphoglycerate synthase, 2,3-Diphosphoglyceromutase, Biphosphoglycerate synthase, bisphosphoglycerate mutase, Bisphosphoglyceromutase, BPG synthase, BPG-dependent PGAM, BPGAM, BPGM, Diphosphoglycerate mutase, Diphosphoglyceric mutase, Diphosphoglyceromutase, DPGM, EC 2.7.5.4, Glycerate phosphomutase, Phosphomutase, glycerate (phosphoglycerate cofactor)

ECTree

     5 Isomerases

         5.4 Intramolecular transferases

             5.4.2 Phosphotransferases (phosphomutases)

                5.4.2.4 Bisphosphoglycerate mutase

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4	Activating Compound
1912	AA Sequence
1	Application
1	CAS Registry Number
10	Cloned(Commentary)
5	Crystallization (Commentary)
69	Disease/ Diagnostics
1	Expression
7	General Information
17	Inhibitors
16	KM Value [mM]
3	Metals/Ions
14	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
32	Organism
3	Pathway
71	PDB ID
1	pH Optimum
1	Posttranslational Modification
3	Protein Variants
13	Purification (Commentary)
2	Reaction
2	Reaction Type
32	Reference
34	Source Tissue
8	Specific Activity [micromol/min/mg]
4	Storage Stability
30	Substrates and Products (Substrate)
7	Subunits
29	Synonyms
1	Systematic Name
4	Temperature Stability [°C]
7	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 5.4.2.4 - Bisphosphoglycerate mutase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2,3-Diphosphoglycerate

?

2 entries

3-phospho-D-glyceroyl phosphate

2,3-bisphospho-D-glycerate

4 entries

2,3-Diphosphoglycerate

?

Homo sapiens

-

multifunctional enzyme for synthesis and degradation of 2,3-diphosphoglycerte, additional activities are diphosphoglycerate phosphatase and phosphoglycerate mutase

3308

-

-

?

2,3-Diphosphoglycerate

?

Homo sapiens

-

in red blood cells 2,3-diphosphoglycerate is the main allosteric effector of hemoglobin, shifting the equilibrium between the oxy and deoxy conformations of hemoglobin preferentially stabilizing the unliganded form. 2,3-Diphosphoglycerate also promotes the polymerization of deoxyhemoglobin in sickle cell disease

3306

-

-

?

3-phospho-D-glyceroyl phosphate

2,3-bisphospho-D-glycerate

Homo sapiens

-

-

660653, 728236, 728437, 748733

-

-

?

3-phospho-D-glyceroyl phosphate

2,3-bisphospho-D-glycerate

Homo sapiens

P07738

-

662264

-

-

?

3-phospho-D-glyceroyl phosphate

2,3-bisphospho-D-glycerate

Homo sapiens

-

BPGM plays a pivotal role in the dissociation of oxygen from hemoglobin via 2,3-bisphospho-D-glycerate

651748

-

651748

?

3-phospho-D-glyceroyl phosphate

2,3-bisphospho-D-glycerate

Mus musculus

-

-

706143

-

-

?