5.3.3.6: methylitaconate DELTA-isomerase

This is an abbreviated version!
For detailed information about methylitaconate DELTA-isomerase, go to the full flat file.

Reaction

Synonyms

(R)-3-methylitaconate isomerase, 3-methylitaconate-DELTA-isomerase, Isomerase, methylitaconate, Isomerase, methylitaconate DELTA-, MeIT isomerase, Methylitaconate isomerase, MII

ECTree

5 Isomerases

5.3 Intramolecular oxidoreductases

5.3.3 Transposing C=C bonds

5.3.3.6 methylitaconate DELTA-isomerase

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Results	in table
3	Activating Compound
507	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
3	Inhibitors
4	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
5	Organism
3	Pathway
2	pH Optimum
2	Purification (Commentary)
1	Reaction
3	Reaction Type
5	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
8	Substrates and Products (Substrate)
1	Subunits
7	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Reference

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Reference on EC 5.3.3.6 - methylitaconate DELTA-isomerase

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2986

Kung, H.F.; Tsai, L.

Nicotinic acid metabolism. VII. Mechanism of action of Clostridial alpha-methyleneglutarate mutase (B12-dependent) and methylitaconate isomerase

J. Biol. Chem.

246

6436-6443

1971

Eubacterium barkeri

5316214

2988

Hartrampf, G.; Buckel, W.

On the steric course of the adenosylcobalamin-dependent 2-methyleneglutarate mutase reaction in Clostridium barkeri

Eur. J. Biochem.

156

301-304

1986

Eubacterium barkeri

3699016

3522

Kung, H.F.; Stadtman, T.C.

Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B12-dependent) and methylitaconate isomerase

J. Biol. Chem.

246

3378-3388

1971

Eubacterium barkeri

5574401

670692

Alhapel, A.; Darley, D.J.; Wagener, N.; Eckel, E.; Elsner, N.; Pierik, A.J.

Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri

Proc. Natl. Acad. Sci. USA

103

12341-12346

2006

Eubacterium barkeri

16894175

705153

Velarde, M.; Macieira, S.; Hilberg, M.; Br�ker, G.; Tu, S.-M.; Golding, B.T.; Pierik, A.J.; Buckel, W.; Messerschmidt, A.

Crystal structure and putative mechanism of 3-methylitaconate-DELTA-isomerase from Eubacterium barkeri

J. Mol. Biol.

391

609-620

2009

Eubacterium barkeri (Q0QLE6), Eubacterium barkeri

19559030