5.1.3.2: UDP-glucose 4-epimerase This is an abbreviated version! For detailed information about UDP-glucose 4-epimerase, go to the full flat file .
Reaction
UDP-alpha-D-glucose =
UDP-alpha-D-galactose
Synonyms 4-Epimerase, 6xHis-rGalE, ABD1_580, An14g03820, AtUGE1, AtUGE2, AtUGE3, AtUGE4, AtUGE5, CaGAL10, CapD, epimerase Ab-WbjB, Epimerase, uridine diphosphoglucose, fnlA, GAL10, Gal10p, Galactowaldenase, GalE, galE-1, galE-2, galE1, GalESp1, GalESp2, GNE, GNE2, H3634, HvUGE1, HvUGE2, HvUGE3, MdUGE1, More, OsUGE-1, OsUGE1, PsUGE1, Rdh1, rGalE, Rv3634c, TbGalE, TM0509, TMGalE, UDP-D-galactose 4-epimerase, UDP-D-glucose/UDP-D-galactose 4-epimerase, UDP-Gal 4-epimerase, UDP-Gal/Glc 4-epimerase, UDP-galactose 4'-epimerase, UDP-galactose 4-epimerase, UDP-galactose-4'-epimerase, UDP-galactose-4-epimerase, UDP-Glc 4-epimerase, UDP-Glc(NAc) 4-epimerase, UDP-GlcNAc 4-epimerase, UDP-GlcNAc/Glc 4-epimerase, UDP-glucose 4'-epimerase, UDP-glucose 4-epimerase, UDP-glucose 4-epimerase 1, UDP-glucose 4-epimerase 4, UDP-glucose epimerase, UDP-glucose-4-epimerase, UDP-glucose/-galactose 4-epimerase, UDP-hexose 4-epimerase, UDP-N-acetyl-glucosamine 4,6-dehydratase, UDP-sugar 4-epimerase, UDP-Xyl 4-epimerase, UDP-xylose 4-epimerase, UDPG-4-epimerase, UDPgalactose 4-epimerase, UGE, UGE-1, UGE1, UGE1:GUS, Uge1p, UGE2, UGE3, UGE3:GUS, UGE4, UGE5, UgeA, Uridine diphosphate galactose 4-epimerase, Uridine diphosphate glucose 4-epimerase, uridine diphosphate-galactose-4'-epimerase, Uridine diphospho-galactose-4-epimerase, Uridine diphosphogalactose-4-epimerase, Uridine diphosphoglucose 4-epimerase, Uridine diphosphoglucose epimerase, uridine-diphospho-glucose 4-epimerase, WbjB
ECTree
Natural Substrates Products
Natural Substrates Products on EC 5.1.3.2 - UDP-glucose 4-epimerase
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
UDP-D-glucose
UDP-D-galactose
UDP-D-xylose
UDP-L-arabinose
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r
UDP-galactose
UDP-glucose
UDP-glucose
UDP-galactose
UDP-N-acetyl-alpha-D-glucosamine
UDP-N-acetyl-alpha-D-galactosamine
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?
additional information
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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?
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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?
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
the NAD+-dependent enzyme is responsible for reversibly inverting the 4-hydroxyl configuration of UDP-alpha-D-galactose to form UDP-alpha-D-glucose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
via 4-ketose intermediate
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
Q81JK4, Q81K34
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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?
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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The enzyme UDP-glucose 4'-epimerase (GalE) interconverts UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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The enzyme UDP-glucose 4'-epimerase (GalE) interconverts UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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?
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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anthocyanin biosynthesis
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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r
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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?
UDP-alpha-D-glucose
UDP-alpha-D-galactose
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Leloir pathway of membrane polysaccharide synthesis
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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the enzyme catalyzes the conversion of UDP-galactose to UDP-glucose, an important biochemical step in exopolysaccharide synthesis
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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the enzyme catalyzes the conversion of UDP-galactose to UDP-glucose, an important biochemical step in exopolysaccharide synthesis
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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Galactose metabolism is essential for the survival of Trypanosoma brucei, the etiological agent of African sleeping sickness.
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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The enzyme UDP-glucose 4'-epimerase (GalE) interconverts UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal).
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-alpha-D-glucose
UDP-alpha-D-galactose
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UDP-D-glucose
UDP-D-galactose
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UDP-D-glucose
UDP-D-galactose
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carbohydrate biosynthesis
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UDP-D-glucose
UDP-D-galactose
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carbohydrate catabolism
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UDP-D-glucose
UDP-D-galactose
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UDP-galactose
UDP-glucose
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UDP-galactose
UDP-glucose
Q81JK4, Q81K34
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UDP-galactose
UDP-glucose
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the bifunctional enzyme UDP-GlcNAc/Glc 4-epimerase is the sole supplier of the UDP-galactose and UDP-GalNAc required for synthesis of lipooligosaccharide
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UDP-galactose
UDP-glucose
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glycolysis and TCA cycle, Leloir pathway
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UDP-galactose
UDP-glucose
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enzyme catalyzes the first step of the Lelpoir pathway
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UDP-galactose
UDP-glucose
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galactose metabolic pathway
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UDP-galactose
UDP-glucose
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enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules
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UDP-galactose
UDP-glucose
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final step of the Leloir pathway
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UDP-galactose
UDP-glucose
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point mutations in UDP-galactose 4-epimerase are associated with the genetic disease, type III galactosemia
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UDP-galactose
UDP-glucose
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UDP-galactose
UDP-glucose
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UDP-galactose
UDP-glucose
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Leloir pathway of D-galactose catabolism
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UDP-galactose
UDP-glucose
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Leloir pathway of galactose metabolism
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UDP-galactose
UDP-glucose
glycolysis and TCA cycle, Leloir pathway
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UDP-galactose
UDP-glucose
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UDP-GalNAc
UDP-GlcNAc
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the bifunctional enzyme UDP-GlcNAc/Glc 4-epimerase is the sole supplier of the UDP-galactose and UDP-GalNAc required for synthesis of lipooligosaccharide. The enzyme supplies the UDP-GalNAc required for the synthesis of the capsule
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UDP-GalNAc
UDP-GlcNAc
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enzyme contributes to the Lelpoir pathway and also functions as a gatekeeper overseeing the ratios of important substrate pools required for the synthesis of glycosylated macromolecules
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UDP-Glc
UDP-Gal
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UDP-Glc
UDP-Gal
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UDP-GlcNAc
UDP-GalNAc
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UDP-GlcNAc
UDP-GalNAc
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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UDP-glucose
UDP-galactose
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additional information
?
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Leloir pathway of galactose metabolism
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?
additional information
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Q81JK4
the gene encodes a bifunctional enzyme with both UDP-GlcNAc 4-epimerase and UDP-Glc 4-epimerase activities and that no other annotated UDP-Glc 4-epimerase gene encodes a UDP-GlcNAc 4-epimerase
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?
additional information
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Q81K34
the gene encodes a bifunctional enzyme with both UDP-GlcNAc 4-epimerase and UDP-Glc 4-epimerase activities and that no other annotated UDP-Glc 4-epimerase gene encodes a UDP-GlcNAc 4-epimerase
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additional information
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the gene encodes a bifunctional enzyme with both UDP-GlcNAc 4-epimerase and UDP-Glc 4-epimerase activities and that no other annotated UDP-Glc 4-epimerase gene encodes a UDP-GlcNAc 4-epimerase
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?
additional information
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Q81JK4
UDP-N-acetylgalactoseamine 4-epimerase encoded by gene BAS5304 also shows UDP-glucose 4-epimerase activity, overview
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?
additional information
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Q81K34
UDP-N-acetylgalactoseamine 4-epimerase encoded by gene BAS5304 also shows UDP-glucose 4-epimerase activity, overview
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additional information
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UDP-N-acetylgalactoseamine 4-epimerase encoded by gene BAS5304 also shows UDP-glucose 4-epimerase activity, overview
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additional information
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enzyme of galactose metabolism
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additional information
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impairement of the enzyme results in galacosemia III that can lead to symptoms ranging from benign to severe
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additional information
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during fruit development, no significant correlation occurs between the changes in UGE activity and UDP-sugar contents, overview
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additional information
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xylose-inducible gene
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additional information
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xylose-inducible gene
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?
additional information
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the enzyme is involved in the control of the biosynthesis of cell-wall polysaccharides containing D-galactose
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?
additional information
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Saccharomyces fragilis
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enzyme may play a regulatory role in controlling the flux of galactose metabolism
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?
additional information
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Gal10p, a Gal-1-P uridylyltransferase, also shows UDP-glucose/-galactose 4-epimerase activity, overview
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additional information
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Gal10p, a Gal-1-P uridylyltransferase, also shows UDP-glucose/-galactose 4-epimerase activity, overview
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additional information
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Gal10p, a Gal-1-P uridylyltransferase, also shows UDP-glucose/-galactose 4-epimerase activity, overview
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additional information
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both enzymatic activities, as uridine diphosphate-galactose-4'-epimerase and UDP-N-acetylglucosamine-4'-epimerase, reveal that enzyme from Thermus thermophilus HB8 show dual functions for catalyzing conversion of UDP-glucose to UDP-galactose and between their N-acetylated forms
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?