5.1.1.9: arginine racemase
This is an abbreviated version!
For detailed information about arginine racemase, go to the full flat file.
Word Map on EC 5.1.1.9
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5.1.1.9
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racemization
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transamination
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dithiothreitol
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graveolens
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pyridoxal
- 5.1.1.9
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racemization
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transamination
- dithiothreitol
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graveolens
- pyridoxal
Reaction
Synonyms
arginine racemase, ArgR, Racemase, arginine
ECTree
5.1.1.9 arginine racemaseAdvanced search results
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Substrates Products on EC 5.1.1.9 - arginine racemase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
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Pseudomonas graveolens
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the enzyme catylzes transamination between L-Orn or D-Orn and pyruvate with the formation of racemic Ala and DELTA1-pyrroline-2-carboxylic acid. The rate of transamination is very low as compared to that of racemization
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-
?
D-alanine
L-alanine
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11% activity compared to D-arginine
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-
?
D-arginine
L-arginine
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racemization of arginine is a two-step mechanism, intermediate is 2-keto-arginine, a first enzyme (DauA) catalyzes oxidative deamination of D-arginine into 2-ketoarginine and ammonia, and the second enzyme DauB is able to use 2-ketoarginine and ammonia as substrates and convert them into L-arginine in the presence of NADPH or NADH, DauA and DauB are coupled catabolic and anabolic dehydrogenases to perform D-to-L racemization of arginine, which serves as prerequisite of D-arginine utilization through L-arginine catabolic pathways
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ir
L-alanine
D-alanine
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12% activity compared to L-arginine
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-
?
L-Citrulline
D-Citrulline
Pseudomonas graveolens
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13% of the activity relative to L-Arg
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?
L-Ethionine
D-Ethionine
Pseudomonas graveolens
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13% of the activity relative to L-Arg
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?
L-Homoarginine
D-Homoarginine
Pseudomonas graveolens
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25% of the activity relative to L-Arg
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?
L-Homocitrulline
D-Homocitrulline
Pseudomonas graveolens
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12% of the activity relative to L-Arg
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?
L-Ornithine
D-Ornithine
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44% activity compared to L-arginine
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-
?
