5.1.1.15: 2-aminohexano-6-lactam racemase

This is an abbreviated version!
For detailed information about 2-aminohexano-6-lactam racemase, go to the full flat file.

Word Map on EC 5.1.1.15

5.1.1.15

synthesis

amide

racemization

d-aminopeptidase

5'-phosphate

ochrobactrum

pyridoxal

anthropi

Reaction

Synonyms

ACL racemase, ACLR, alpha-Amino-delta-valerolactam racemase, alpha-Amino-epsilon-caprolactam racemase, Aminocaprolactam racemase, moe, More, Racemase, alpha-amino-epsilon-caprolactam, Racemase, alpha-amino-epsilon-caprolactam (Achromobacter obae reduced), SMc02413

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.15 2-aminohexano-6-lactam racemase

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Results	in table
15	AA Sequence
20	Application
2	CAS Registry Number
17	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
4	General Information
2	General Stability
61	Inhibitors
6	kcat/KM [mM/s]
19	KM Value [mM]
2	Localization
5	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
35	Organism
5	PDB ID
20	pH Optimum
7	pH Range
8	pH Stability
18	Purification (Commentary)
4	Reaction
2	Reaction Type
33	Reference
45	Specific Activity [micromol/min/mg]
3	Storage Stability
98	Substrates and Products (Substrate)
6	Subunits
77	Synonyms
1	Systematic Name
14	Temperature Optimum [°C]
2	Temperature Range [°C]
11	Temperature Stability [°C]
6	Turnover Number [1/s]

General Information

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General Information on EC 5.1.1.15 - 2-aminohexano-6-lactam racemase

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evolution

2 entries

malfunction

Achromobacter obae

Q7M181

the mutation of either Asp210 or Lys267 to alanine abolish the racemization activity for 2-aminohexano-6-lactam

746781

additional information

Achromobacter obae

Q7M181

analysis of the structure-function relationship, overview. Lys241 is a key amino acid residue, active site structure of ACL racemase. The substrate binding site is typically located between Trp49 and Tyr137. Lys241 Nepsilon is considered to be important for recognizing the carbonyl O of the substrate. Lys241 also forms a salt bridge with Glu396. Asp210 and Lys267 are two plausible acid/base catalytic candidate residues, situated on the re and si faces of the pyridoxal 5'-phosphate ring, respectively. The racemization of ACL racemase proceeds via a two-base mechanism

746781