4.4.1.35: L-cystine beta-lyase

This is an abbreviated version!
For detailed information about L-cystine beta-lyase, go to the full flat file.

Reaction

Synonyms

BOCL3, cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming), CORI3

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.35 L-cystine beta-lyase

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
2	Cofactor
8	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
2	Localization
10	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
2	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
5	Purification (Commentary)
4	Reaction
4	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
20	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 4.4.1.35 - L-cystine beta-lyase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-aminoprop-2-enoate

2-iminopropanoate

Brassica oleracea var. italica

-

-

741128

spontaneous partial reaction

-

?

2-iminopropanoate + H2O

pyruvate + NH3

Brassica oleracea var. italica

-

-

741128

spontaneous partial reaction

-

?

L-cysteine S-sulfate + H2O

?

Brassica oleracea var. italica

-

-

651551

-

-

?

L-cystine

L-thiocysteine + 2-aminoprop-2-enoate

Brassica oleracea var. italica

-

-

741128

-

-

?

L-cystine + H2O

L-thiocysteine + pyruvate + NH3

3 entries

L-djenkolic acid + H2O

?

Brassica oleracea var. italica

-

18-24% of the activity with L-cystine

651551

-

-

?

S-ethyl L-cysteine + H2O

?

Brassica oleracea var. italica

-

71% of the activity with L-cystine

651551

-

-

?

S-ethyl L-cysteine sulfoxide + H2O

?

3 entries

S-methyl L-cysteine + H2O

?

Brassica oleracea var. italica

-

29% of the activity with L-cystine

651551

-

-

?

S-methyl L-cysteine sulfoxide + H2O

?

3 entries

S-propyl L-cysteine + H2O

?

Brassica oleracea var. italica

-

29% of the activity with L-cystine

651551

-

-

?

additional information

?

-

2 entries

L-cystine + H2O

L-thiocysteine + pyruvate + NH3

Arabidopsis thaliana

Q9SUR6

-

652362

-

-

?

L-cystine + H2O

L-thiocysteine + pyruvate + NH3

Brassica oleracea var. italica

-

-

741128

-

-

?

L-cystine + H2O

L-thiocysteine + pyruvate + NH3

Brassica oleracea var. italica

-

-

651551, 741128

overall reaction

-

?

S-ethyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

-

741128

-

-

?

S-ethyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

48% of the activity with L-cystine

741128

-

-

?

S-ethyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

64% of the activity with L-cystine

741128

-

-

?

S-methyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

-

741128

-

-

?

S-methyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

37% of the activity with L-cystine

741128

-

-

?

S-methyl L-cysteine sulfoxide + H2O

?

Brassica oleracea var. italica

-

46% of the activity with L-cystine

741128

-

-

?

additional information

?

-

Brassica oleracea var. italica

-

the enzyme catalyzes beta-elimination of L-cystine to yield thiocysteine, pyruvate and possibly ammonia. S-Methyl L-cysteine sulfoxide and S-ethyl L-cysteine sulfoxide are substrates but are less suitable than L-cystine. No substrates: D-cystine, L- and o-cysteine and cystathionine

741128

-

-

?

additional information

?

-

Brassica oleracea var. italica

-

negligible activity with L-cystathionine

651551

-

-

?