4.4.1.35: L-cystine beta-lyase

This is an abbreviated version!
For detailed information about L-cystine beta-lyase, go to the full flat file.

Reaction

Synonyms

BOCL3, cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming), CORI3

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.35 L-cystine beta-lyase

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
2	Cofactor
8	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
2	Localization
10	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
4	Organism
2	Pathway
2	pH Optimum
1	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
5	Purification (Commentary)
4	Reaction
4	Reference
1	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
20	Substrates and Products (Substrate)
4	Subunits
4	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]

Systematic Name

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Systematic Name on EC 4.4.1.35 - L-cystine beta-lyase

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SYSTEMATIC NAME

IUBMB Comments

L-cystine thiocysteine-lyase (deaminating; pyruvate-forming)

A pyridoxal 5'-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-thiocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from Brassica oleracea var. italica (broccoli) does not act on cysteine or cystathionine.