4.2.99.22: tuliposide A-converting enzyme
This is an abbreviated version!
For detailed information about tuliposide A-converting enzyme, go to the full flat file.
Word Map on EC 4.2.99.22
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4.2.99.22
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tulipalins
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gesneriana
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carboxylesterase
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bulb
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transesterification
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synthesis
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tfiis
- 4.2.99.22
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tulipalins
- gesneriana
- carboxylesterase
- bulb
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transesterification
- synthesis
- tfiis
Reaction
Synonyms
6-O-(4'-hydroxy-2'-methylenebutyryl)-D-glucose acyltransferase (lactone-forming), ignition enzyme, non-ester-hydrolyzing TCE, Pos-converting enzyme, PosA-converting enzyme, TCE, TCEA, TCEA-b1, TCEA1, TgTCEA1, tuliposide A converting enzyme, tuliposide-converting enzyme
ECTree
4.2.99.22 tuliposide A-converting enzymeAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.99.22 - tuliposide A-converting enzyme
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
tuliposide F
(3R)-3-hydroxy-2-methylidenecyclopentan-1-one + 1-tuliposide A
i.e. PosF, the enzyme catalyzes intramolecular transesterification, PosF is a 1,6-diacyl-glucose type of Pos, the enzyme shows 55% activity with PosF compared to 6-PosA, the configuration at the C-3' position of the substrate PosF is S-form
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?
1,6-tuliposide D
tulipalin A + 1-tuliposide A
i.e. PosD, the enzyme catalyzes intramolecular transesterification, PosD is a 1,6-diacyl-glucose type of Pos, the enzyme shows 250% activity with PosD compared to 6-PosA, best substrate
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?
6-tuliposide A
tulipalin A + D-glucose
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enzyme accepts 6-tuliposide A to catalyze only the intramolecular transesterification but not the hydrolysis
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?
6-tuliposide A
tulipalin A + D-glucose
i.e. 6-O-(4-hydroxy-2-methylenebutanoyl)-D-glucose
i.e. 2-methylenebutanolactone
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?
6-tuliposide A
tulipalin A + D-glucose
i.e. 6-PosA, a monoacyl-glucose type of Pos, the enzyme catalyzes intramolecular transesterification, high activity
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?
6-tuliposide B
tulipalin B + D-glucose
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7.8% of the activity with 6-tuliposide A
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?
6-tuliposide B
tulipalin B + D-glucose
8.7% of the activity with 6-tuliposide A
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?
6-tuliposide B
tulipalin B + D-glucose
i.e. 6-PosB, a monoacyl-glucose type of Pos, the enzyme catalyzes intramolecular transesterification, the enzyme shows 4.6% activity with 6-PosB compared to 6-PosA
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?
6-tuliposide B
tulipalin B + D-glucose
i.e. 6-PosB, enzyme TCEA shows 7-8% activity with 6-PosB compared to 6-PosA
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?
additional information
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TCE enzymes are lactone-forming enzymes and a non-ester-hydrolyzing carboxylesterase, and specifically catalyze intramolecular transesterification, but not hydrolysis
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?
additional information
?
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TCE enzymes are lactone-forming enzymes and a non-ester-hydrolyzing carboxylesterase, and specifically catalyze intramolecular transesterification, but not hydrolysis
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?
additional information
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6-tuliposide A (6-PosA) is chemically labile, and they can be spontaneously converted to PaA in neutral to weakly basic conditions in vitro. 1-Tuliposide A (1-PosA) is no substrate
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?
additional information
?
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enzyme TCEA preferentially catalyzes the conversion of 6-PosA to PaA, but it also shows activity for 6-PosB, at about 7-8% relative to that of 6-PosA. TCEA catalyzes intramolecular transesterification of 6-tuliposide A (6-PosA) to form tulipalins A (PaA), but neither the hydrolysis of 6-Pos nor Pa. 1alpha- and 1beta-anomers exist for 6-PosA, and both anomers serve as substrates for TCEA
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?
additional information
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enzyme TCEA preferentially catalyzes the conversion of 6-PosA to PaA, but it also shows activity for 6-PosB, at about 7-8% relative to that of 6-PosA. TCEA catalyzes intramolecular transesterification of 6-tuliposide A (6-PosA) to form tulipalins A (PaA), but neither the hydrolysis of 6-Pos nor Pa. 1alpha- and 1beta-anomers exist for 6-PosA, and both anomers serve as substrates for TCEA
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?
