4.2.3.B19: (-)-beta-curcumene synthase

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For detailed information about (-)-beta-curcumene synthase, go to the full flat file.

Reaction

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.B19 (-)-beta-curcumene synthase

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1	Crystallization (Commentary)
3	kcat/KM [mM/s]
3	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
2	Organism
1	pH Optimum
1	Reaction
2	Reference
3	Substrates and Products (Substrate)
1	Systematic Name
1	Temperature Optimum [°C]
3	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.2.3.B19 - (-)-beta-curcumene synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(2Z,6E)-farnesyl diphosphate

(-)-beta-curcumene + diphosphate

2 entries

(2Z,6E)-farnesyl diphosphate

(-)-beta-curcumene + diphosphate

Nicotiana tabacum

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701441

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?

(2Z,6E)-farnesyl diphosphate

(-)-beta-curcumene + diphosphate

Nicotiana tabacum

-

formation of seven bisabolyl-derived sesquiterpenes through the intermediacy of a common (7R)-beta-bisabolyl cation, (+)-2-epiprezizaene (44%) is the major product, (-)-alpha-cedrene (21.5%), (R)-(-)-beta-curcumene (15.5%), alpha-acoradiene (3.9%), 4-epi-alpha-acoradiene (1.3%), and equal amounts of alpha-bisabolol (1.8%) and epi-alpha-bisabolol (1.8%). The enzyme may be able to exploit the low natural levels (3-14%) of (2Z,6E)-farnesyl diphosphate generated by farnesyl diphosphate synthases to produce a different array of sesquiterpenes in vivo. If the concentration of (2E,2E)-farnesyl diphosphate is depleted by its diversion into biosynthesis of phytosterols, farnesylated proteins, or diterpenes, the enzyme would be capable of utilizing (2Z,6E)-farnesyl diphosphate in its place

704204

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?