4.2.3.39: epi-cedrol synthase
This is an abbreviated version!
For detailed information about epi-cedrol synthase, go to the full flat file.
Word Map on EC 4.2.3.39
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4.2.3.39
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sesquiterpene
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annua
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artemisia
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synthases
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artemisinin
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cyclases
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cyclization
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antimalarial
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pyrophosphate
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terpene
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amorpha-4,11-diene
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e-beta-farnesene
- 4.2.3.39
-
sesquiterpene
- annua
-
artemisia
- synthases
- artemisinin
- cyclases
-
cyclization
-
antimalarial
- pyrophosphate
-
terpene
- amorpha-4,11-diene
-
e-beta-farnesene
Reaction
Synonyms
8-epicedrol synthase, EPCS, epicedrol synthase, sesquiterpene cyclase
ECTree
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Reaction
Reaction on EC 4.2.3.39 - epi-cedrol synthase
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(2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate
reaction mechanism, overview
(2E,6E)-farnesyl diphosphate + H2O = 8-epi-cedrol + diphosphate
reaction mechanism and cyclization of 8-epi-cedrol. Allylic carbocation formation, isomerization to nerolidyl diphosphate, and cyclization generate the monocyclic bisabolyl cation, a hydride shift is followed by two cyclizations to yield the cedryl cation, and the reaction is terminated by quenching the tricyclic cation with a hydroxide equivalent to form 8-epicedrol, overview