4.2.3.39: epi-cedrol synthase
This is an abbreviated version!
For detailed information about epi-cedrol synthase, go to the full flat file.
Word Map on EC 4.2.3.39
-
4.2.3.39
-
sesquiterpene
-
annua
-
artemisia
-
synthases
-
artemisinin
-
cyclases
-
cyclization
-
antimalarial
-
pyrophosphate
-
terpene
-
amorpha-4,11-diene
-
e-beta-farnesene
- 4.2.3.39
-
sesquiterpene
- annua
-
artemisia
- synthases
- artemisinin
- cyclases
-
cyclization
-
antimalarial
- pyrophosphate
-
terpene
- amorpha-4,11-diene
-
e-beta-farnesene
Reaction
Synonyms
8-epicedrol synthase, EPCS, epicedrol synthase, sesquiterpene cyclase
ECTree
4.2.3.39 epi-cedrol synthaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 4.2.3.39 - epi-cedrol synthase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
geranyl diphosphate + H2O
? + diphosphate
geranyl diphosphate is converted to monoterpenes by the recombinant enzyme at a rate of about 15% of that observed with farnesyl diphosphate as substrate
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
8-epi-cedrol + diphosphate
the enzyme is involved in the artemisinin biosynthesis pathway, overview
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
8-epi-cedrol + diphosphate
-
the enzyme is involved in the artemisinin biosynthesis pathway, overview
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
8-epi-cedrol + diphosphate
the native enzyme is specific for farnesyl diphosphate as substrate
-
-
?
(2E,6E)-farnesyl diphosphate + H2O
8-epi-cedrol + diphosphate
the native enzyme is specifically producing 8-epi-cedrol, but the enzyme recombinantly expressed in Escherichia coli also produces cedrol, with 8-epi-cedrol and cedrol in a 96:4 ratio, GC-MS product analysis, overview
-
-
?
additional information
?
-
Sesquiterpene cyclases or synthases catalyze the conversion of the isoprenoid intermediate farnesyl diphosphate to various sesquiterpene structural types
-
-
?
additional information
?
-
-
Sesquiterpene cyclases or synthases catalyze the conversion of the isoprenoid intermediate farnesyl diphosphate to various sesquiterpene structural types
-
-
?
additional information
?
-
product formation specificity, overview. Native epi-cedrol synthase is not active with geranylgeranyl diphosphate as substrate. The recombinant enzyme catalyzes the formation of both olefinic sesquiterpene, i.e. 57% alpha-cedrene, 13% beta-cedrene, 5% (E)-beta-farnesene , 1% alpha-acoradiene, 8% (E)-alpha-bisabolene, and 16% of three unknown olefins, but mainly oxygenates sesquiterpenes, 97% of total sesquiterpene generated, composed of 96% epi-cedrol and 4% cedrol, from farnesyl diphosphate, GC-MS product analysis, overview
-
-
?
additional information
?
-
-
product formation specificity, overview. Native epi-cedrol synthase is not active with geranylgeranyl diphosphate as substrate. The recombinant enzyme catalyzes the formation of both olefinic sesquiterpene, i.e. 57% alpha-cedrene, 13% beta-cedrene, 5% (E)-beta-farnesene , 1% alpha-acoradiene, 8% (E)-alpha-bisabolene, and 16% of three unknown olefins, but mainly oxygenates sesquiterpenes, 97% of total sesquiterpene generated, composed of 96% epi-cedrol and 4% cedrol, from farnesyl diphosphate, GC-MS product analysis, overview
-
-
?
