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4.2.3.35: syn-pimara-7,15-diene synthase

This is an abbreviated version!
For detailed information about syn-pimara-7,15-diene synthase, go to the full flat file.

Word Map on EC 4.2.3.35

Reaction

9alpha-copalyl diphosphate
=
9beta-pimara-7,15-diene
 +
diphosphate

Synonyms

9beta-pimara-7,15-diene synthase, DTC1, OsDTS2, OsKS4

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.3 Acting on phosphates
                4.2.3.35 syn-pimara-7,15-diene synthase

Engineering

Engineering on EC 4.2.3.35 - syn-pimara-7,15-diene synthase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A713S
products are isopimaradiene and sandaracopimaradiene
G651V
no change in product
V717L
no change in product
W679L/Y686H/A713S/V717L
products are isopimaradiene and sandaracopimaradiene
Y686H
no change in product
Y686H/A713S
main products are isopimaradiene and sandaracopimaradiene
Y686H/A713S A713S
main products are isopimaradiene and sandaracopimaradiene
Y686H/A713S/V717L
products are isopimaradiene and sandaracopimaradiene
additional information
swapping of residues 568–640 of isopimaradiene synhase to corresponding residues 560-632 of levopimaradiene/abietadiene synthase results in complete reversion of the product profiles of the two enzymes