4.2.3.24: amorpha-4,11-diene synthase

This is an abbreviated version!
For detailed information about amorpha-4,11-diene synthase, go to the full flat file.

Word Map on EC 4.2.3.24

4.2.3.24

artemisia

annua

sesquiterpene

antimalarial

cyp71av1

artemisinic

terpene

dihydroartemisinic

trichomes

sesquiterpenoids

endoperoxide

wormwood

medicine

artemisinin-based

drug development

pharmacology

agriculture

synthesis

Reaction

Synonyms

ADS, ADS1, ADS3963, amorpha-4,11-diene synthase, amorphadiene synthase, AMS

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.24 amorpha-4,11-diene synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
3	AA Sequence
11	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Crystallization (Commentary)
2	Expression
2	General Information
1	IC50 Value
10	Inhibitors
19	kcat/KM [mM/s]
22	KM Value [mM]
1	Localization
8	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
32	Organism
5	Pathway
2	PDB ID
5	pH Optimum
2	pH Range
3	pI Value
1	Posttranslational Modification
58	Protein Variants
7	Purification (Commentary)
4	Reaction
6	Reaction Type
31	Reference
1	Renatured (Commentary)
15	Source Tissue
66	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
6	Subunits
32	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
19	Turnover Number [1/s]

Systematic Name

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Systematic Name on EC 4.2.3.24 - amorpha-4,11-diene synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Systematic Name Search

(2E,6E)-farnesyl diphosphate diphosphate-lyase (amorpha-4,11-diene-forming)

Requires Mg2+ and Mn2+ for activity. This is a key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin [3]. Catalyses the formation of both olefinic [e.g. amorpha-4,11-diene, amorpha-4,7(11)-diene, gamma-humulene and beta-sesquiphellandrene] and oxygenated (e.g. amorpha-4-en-7-ol) sesquiterpenes, with amorpha-4,11-diene being the major product. When geranyl diphosphate is used as a substrate, no monoterpenes are produced [2].