4.2.3.24: amorpha-4,11-diene synthase

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For detailed information about amorpha-4,11-diene synthase, go to the full flat file.

Word Map on EC 4.2.3.24

4.2.3.24

artemisia

annua

sesquiterpene

antimalarial

cyp71av1

artemisinic

terpene

dihydroartemisinic

trichomes

sesquiterpenoids

endoperoxide

wormwood

medicine

artemisinin-based

drug development

pharmacology

agriculture

synthesis

Reaction

Synonyms

ADS, ADS1, ADS3963, amorpha-4,11-diene synthase, amorphadiene synthase, AMS

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.24 amorpha-4,11-diene synthase

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Results	in table
3	AA Sequence
11	Application
1	CAS Registry Number
16	Cloned(Commentary)
1	Crystallization (Commentary)
2	Expression
2	General Information
1	IC50 Value
10	Inhibitors
19	kcat/KM [mM/s]
22	KM Value [mM]
1	Localization
8	Metals/Ions
8	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
32	Organism
5	Pathway
2	PDB ID
5	pH Optimum
2	pH Range
3	pI Value
1	Posttranslational Modification
58	Protein Variants
7	Purification (Commentary)
4	Reaction
6	Reaction Type
31	Reference
1	Renatured (Commentary)
15	Source Tissue
66	Specific Activity [micromol/min/mg]
34	Substrates and Products (Substrate)
6	Subunits
32	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
19	Turnover Number [1/s]

Crystallization

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Crystallization on EC 4.2.3.24 - amorpha-4,11-diene synthase

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Go to Crystallization (commentary) Search

3D-modeling of structure. Predicted model shows that the putative ADS3963 protein contains 72% of alpha-helices, 23% beta-turns and 26% of random coils. Based on docking studies with substrate farnesyl diphosphate, the stretches Ala321-Ala324-Lys-398, Ala234-Val237-Phe283-Thr286-Tyr-287, Ser94-Met95-Trp141-Trp430-Asn434, Ser94-Arg96-Glu104-Leu107-Lys142-Lys431, Lys137-Arg143-Ile147-Ala150-Gln151-Leu478 and Ser218-Gly219-Tyr224-Arg228-Cys352-Met356-Aln450 may constitute to substrate binding

Artemisia annua

Q9AR04

714386