4.2.3.135: DELTA6-protoilludene synthase
This is an abbreviated version!
For detailed information about DELTA6-protoilludene synthase, go to the full flat file.
Word Map on EC 4.2.3.135
Reaction
Synonyms
6-protoilludene synthase, DELTA6-protoilludene sesquiterpene synthase, Omp6, OMP7, PpSTS-08, protoilludene synthase, Stehi25180, Stehi64702, Stehi73029
ECTree
4.2.3.135 DELTA6-protoilludene synthaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.3.135 - DELTA6-protoilludene synthase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
DELTA6-protoilludene + diphosphate
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?
(2E,6E)-farnesyl diphosphate
DELTA6-protoilludene + diphosphate
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single product
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?
(2E,6E)-farnesyl diphosphate
DELTA6-protoilludene + diphosphate
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main product for isoforms 25180, 64702, 73029. Isoforms 64702 and 73029 appear to be less specific than other previously described DELTA6-protoilludene synthases, and are capable of simultaneously producing a 1,10-cyclization-derived scaffold, beta-elemene, when expressed in a heterologous host
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?
additional information
?
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in the presence of Ca2+, DELTA6-protoilludene synthases catalyze diverse cyclization reactions. DELTA6-Protoilludene and (E)-beta-caryophyllene result from a 1,11 cyclization of (2E,6E)-FPP following metal ion mediated ionization. The intermediate trans-humulyl cation may undergo a hydride shift followed by two cyclizations and a deprotonation to yield DELTA6-protoilludene. Diphosphate enzyme-coupled spectrophotometric assay
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?
additional information
?
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product formation is identified and quantified by GC-MS analysis
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?
additional information
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PpSTS-08 product formation is identified by GC-MS and NMR analysis
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?
additional information
?
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in the presence of Ca2+, DELTA6-protoilludene synthases catalyze diverse cyclization reactions. DELTA6-Protoilludene and (E)-beta-caryophyllene result from a 1,11 cyclization of (2E,6E)-farnesyl diphosphate following metal ion mediated ionization. The intermediate trans-humulyl cation may undergo a hydride shift followed by two cyclizations and a deprotonation to yield DELTA6-protoilludene. Diphosphate enzyme-coupled spectrophotometric assay
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?
additional information
?
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in the presence of Ca2+, DELTA6-protoilludene synthases catalyze diverse cyclization reactions. DELTA6-Protoilludene and (E)-beta-caryophyllene result from a 1,11-cyclization of (2E,6E)-farnesyl diphosphate following metal ion mediated ionization. The intermediate trans-humulyl cation may undergo a hydride shift followed by two cyclizations and a deprotonation to yield DELTA6-protoilludene Diphosphate enzyme-coupled spectrophotometric assay
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