4.2.3.133: alpha-copaene synthase

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For detailed information about alpha-copaene synthase, go to the full flat file.

Reaction

Synonyms

(Z)-beta-cubebene/alpha-copaene synthase, alpha-copaene synthase, bifunctional sesquiterpene synthase 1, CsSesquiTPS1, SES1, sesquiterpene synthase, sesquiterpene synthase 1, SeTPS1, TPS04, TPS1, TPS2

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.133 alpha-copaene synthase

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Results	in table
14	AA Sequence
2	Application
5	Cloned(Commentary)
1	Expression
2	General Information
1	KM Value [mM]
1	Metals/Ions
2	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
8	Organism
1	Purification (Commentary)
1	Reaction
7	Reference
10	Source Tissue
9	Substrates and Products (Substrate)
2	Subunits
13	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.2.3.133 - alpha-copaene synthase

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(2E,6E)-farnesyl diphosphate

(+)-delta-cadinene + diphosphate

Ricinus communis

B9S9Z3

720640

yield of 40% (+)-delta-cadinene

(2E,6E)-farnesyl diphosphate

(-)-alpha-copaene + diphosphate

3 entries

(2E,6E)-farnesyl diphosphate

alpha-copaene + diphosphate

Helianthus annuus

Q4U3F6

702923

delta-cadinene is one of the two main products, while alpha-muuorlene, beta-caryophyllene, alpha-humulene and alpha-copaene are minor products

2 (2E,6E)-farnesyl diphosphate

(-)-alpha-copaene + delta-cadinene + 2 diphosphate

Liquidambar formosana

748444

2 (2E,6E)-farnesyl diphosphate

alpha-copaene + delta-cadinene + 2 diphosphate

Phyla dulcis

J7LP58

718701

bifunctional sesquiterpene synthase producing both alpha-copaene and delta-cadinene

geranylgeranyl diphosphate + H2O

(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate

Salvia sclarea

J9PDV7

it is proposed that a basic amino acid residue of the enzyme abstracts a proton from a molecule of water as the hydroxyl adds to the double bond at carbon7 of geranylgeranyl diphosphate. Concerted cyclization occurs and the double bond at carbon14 of geranylgeranyl diphosphate (carbon-3 of (8R)-hydroxy-copalyl diphosphate) is protonated. This concerted mechanism accounts for the addition of a single atom of 18O and a single atom of deuterium to geranylgeranyl diphosphate to form (8R)-hydroxy-copalyl diphosphate

730573

first step in synthesis of sclareol