4.2.1.90: L-rhamnonate dehydratase
This is an abbreviated version!
For detailed information about L-rhamnonate dehydratase, go to the full flat file.
Word Map on EC 4.2.1.90
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4.2.1.90
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stipitis
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azotobacter
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vinelandii
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l-lactaldehyde
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pichia
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nonphosphorylated
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ladhs
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1-dehydrogenase
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l-lactate
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niger
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entner-doudoroff
- 4.2.1.90
- stipitis
-
azotobacter
- vinelandii
- l-lactaldehyde
-
pichia
-
nonphosphorylated
-
ladhs
-
1-dehydrogenase
- l-lactate
- niger
-
entner-doudoroff
Reaction
Synonyms
dehydratase, L-rhamnonate, LRA3, Lra3p, LraC, More, PICST_50672, RhamD, YfaW
ECTree
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Engineering
Engineering on EC 4.2.1.90 - L-rhamnonate dehydratase
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H281N
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme
H329N
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme
additional information
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construction of a DELTAlraC knockout mutant from strain CBS 141257, gene deletion and transcriptomic analysis is performed to elucidate the function of LraC, protoplast-mediated transformations of Aspergillus niger. Deletion of genes lraA, lraB or lraC causes a reduction in expression level of the other genes of the L-rhamnose pathway. Strongly reduced expression levels of lraA, lraB, rhaR, rglB, rgxA and rgaeA are observed in the DELTAlraC mutant upon the 2 h transfer to L-rhamnonate compared to the reference strain. But none of the deletions of genes lraA, lraB or lraC results in accumulation of the inducer of the pathway regulator (RhaR)
additional information
Aspergillus niger CBS 141257
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construction of a DELTAlraC knockout mutant from strain CBS 141257, gene deletion and transcriptomic analysis is performed to elucidate the function of LraC, protoplast-mediated transformations of Aspergillus niger. Deletion of genes lraA, lraB or lraC causes a reduction in expression level of the other genes of the L-rhamnose pathway. Strongly reduced expression levels of lraA, lraB, rhaR, rglB, rgxA and rgaeA are observed in the DELTAlraC mutant upon the 2 h transfer to L-rhamnonate compared to the reference strain. But none of the deletions of genes lraA, lraB or lraC results in accumulation of the inducer of the pathway regulator (RhaR)
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additional information
introduction of genes LRA1-4 or LRA1-3, LRA5 and LAR6 compensats for the L-rhamnose-defective phenotype of an Escherichia coli mutant
additional information
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introduction of genes LRA1-4 or LRA1-3, LRA5 and LAR6 compensats for the L-rhamnose-defective phenotype of an Escherichia coli mutant