4.2.1.55: 3-hydroxybutyryl-CoA dehydratase

This is an abbreviated version!
For detailed information about 3-hydroxybutyryl-CoA dehydratase, go to the full flat file.

Word Map on EC 4.2.1.55

4.2.1.55

thiolase

crotonyl-coa

r-specific

beta-hydroxybutyryl-coa

carboxymethylproline

trans-2-enoyl-coas

enoyl-coenzyme

beta-diketones

Reaction

Synonyms

(R)-specific enoyl-CoA hydratase, CaCRT, CP 24, crotonase, D-3-Hydroxybutyryl coenzyme A dehydratase, D-3-Hydroxybutyryl-CoA dehydratase, Dehydratase, D-3-hydroxybutyryl coenzyme A, ECH 2, Enoyl coenzyme A hydrase (D), enoyl coenzyme A hydratase, enoyl-CoA hydratase 2, Ferp_1035, phaJ

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.55 3-hydroxybutyryl-CoA dehydratase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
781	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
5	Inhibitors
1	Ki Value [mM]
4	KM Value [mM]
6	Natural Substrates/ Products (Substrates)
7	Organism
12	Pathway
6	PDB ID
2	pH Optimum
3	Protein Variants
2	Purification (Commentary)
2	Reaction
2	Reaction Type
7	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
4	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 4.2.1.55 - 3-hydroxybutyryl-CoA dehydratase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to General Information Search

metabolism

2 entries

physiological function

Clostridium acetobutylicum

the enzyme catalyzes the dehydration of 3-hydroxybutyryl-CoA to crotonyl-CoA in the n-butanol biosynthetic pathway, molecular mechanism

746965

additional information

Clostridium acetobutylicum

substrate binding pocket structure and mechanism, overview. CaCRT uses a unique CoA binding mode. The Ser69 residue in CaCRT is hydrogen-bonded with N6 of AcAc-CoA, in contrast to the corresponding Lys101 and Val74 residues in ECH and DmdD, and is involved in the stabilization of the adenine ring. Moreover, Ala24 of CaCRT is located near the phosphate moiety, whereas the corresponding Lys31 residue of DmdD is hydrogen-bonded with this moiety

746965