4.2.1.55: 3-hydroxybutyryl-CoA dehydratase

This is an abbreviated version!
For detailed information about 3-hydroxybutyryl-CoA dehydratase, go to the full flat file.

Reaction

Synonyms

(R)-specific enoyl-CoA hydratase, CaCRT, CP 24, crotonase, D-3-Hydroxybutyryl coenzyme A dehydratase, D-3-Hydroxybutyryl-CoA dehydratase, Dehydratase, D-3-hydroxybutyryl coenzyme A, ECH 2, Enoyl coenzyme A hydrase (D), enoyl coenzyme A hydratase, enoyl-CoA hydratase 2, Ferp_1035, phaJ

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.55 3-hydroxybutyryl-CoA dehydratase

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Results	in table
781	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
5	Inhibitors
1	Ki Value [mM]
4	KM Value [mM]
6	Natural Substrates/ Products (Substrates)
7	Organism
12	Pathway
6	PDB ID
2	pH Optimum
3	Protein Variants
2	Purification (Commentary)
2	Reaction
2	Reaction Type
7	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
16	Substrates and Products (Substrate)
4	Subunits
18	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 4.2.1.55 - 3-hydroxybutyryl-CoA dehydratase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

iodoacetamide

Rhodospirillum rubrum

-

0.01 M, 30% inhibition

5792

iodoacetic acid

Rhodospirillum rubrum

-

0.01 M, 12% inhibition

5792

N-ethylmaleimide

Rhodospirillum rubrum

-

0.01 M, 23% inhibition

5792

oct-2-yn-4-enoyl-CoA

Rattus norvegicus

-

a multifunctional irreversible enzyme inhibitor in fatty acid oxidation mainly targeting mitochondrial trifunctional protein beta-subunit, alsoirreversibly inactivates enoyl-CoA hydratase 2, mechanism for inactivation, overview

694522

p-Substituted mercuribenzoate

Rhodospirillum rubrum

-

3 mM, 65% inhibition

5792