4.2.1.49: urocanate hydratase

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For detailed information about urocanate hydratase, go to the full flat file.

Reaction

Synonyms

4'-Imidazolone-5'-propionate hydro-lyase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, HutU, Hydratase, urocanate, Imidazolonepropionate hydrolase, UROC1, Urocanase

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.1 Hydro-lyases

                4.2.1.49 urocanate hydratase

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Results	in table
22924	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
4	Crystallization (Commentary)
29	Disease/ Diagnostics
1	Expression
7	General Information
1	General Stability
111	Inhibitors
1	Ki Value [mM]
15	KM Value [mM]
15	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
199	Organism
8	Pathway
18	PDB ID
7	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
13	Purification (Commentary)
28	Reaction
1	Reaction Type
82	Reference
17	Source Tissue
18	Specific Activity [micromol/min/mg]
6	Storage Stability
166	Substrates and Products (Substrate)
12	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]

Crystallization

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Crystallization on EC 4.2.1.49 - urocanate hydratase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Pseudomonas putida

-

5744, 5747

hanging-drop vapour-diffusion method, crystallized after removing one of the seven free thiol groups. The crystal structure is solved by multiwavelength anomalous diffraction using a seleno-methionine derivative and then refined at 1.14 A resolution

Pseudomonas putida

P25080

666027

the enzyme is crystallized in several conditions, with the best crystals obtained with 0.04 M dipotassium hydrogen phosphate, 16.00 % (w/v) polyethylene glycol 8000 and 22.0% (v/v) glycerol. X ray diffraction data are collected to 2.61 A resolution. The crystals belong to the monoclinic space group P21, with unit cell parameters a = 85.12, b = 137.63, c = 117.69 A, beta = 94.69° and are suitable for molecular replacement phasing

Trypanosoma cruzi

Q4D9S6

749275