4.2.1.49: urocanate hydratase

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For detailed information about urocanate hydratase, go to the full flat file.

Word Map on EC 4.2.1.49

4.2.1.49

putida

histidase

photoactivation

l-histidine

histidine-pyruvate

formiminoglutamate

medicine

Reaction

3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate

Synonyms

4'-Imidazolone-5'-propionate hydro-lyase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, HutU, Hydratase, urocanate, Imidazolonepropionate hydrolase, UROC1, Urocanase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.1 Hydro-lyases

4.2.1.49 urocanate hydratase

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Results	in table
22924	AA Sequence
1	Application
1	CAS Registry Number
6	Cloned(Commentary)
22	Cofactor
4	Crystallization (Commentary)
29	Disease/ Diagnostics
1	Expression
7	General Information
1	General Stability
111	Inhibitors
1	Ki Value [mM]
15	KM Value [mM]
15	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
199	Organism
8	Pathway
18	PDB ID
7	pH Optimum
1	pH Range
1	pI Value
3	Protein Variants
13	Purification (Commentary)
28	Reaction
1	Reaction Type
82	Reference
17	Source Tissue
18	Specific Activity [micromol/min/mg]
6	Storage Stability
166	Substrates and Products (Substrate)
12	Subunits
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Temperature Range [°C]
3	Temperature Stability [°C]

Engineering

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Engineering on EC 4.2.1.49 - urocanate hydratase

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Go to Protein Variants Search

L70P/R450C

Homo sapiens

L70P and R450C mutations in the coding region of the UROC1 gene in a girl with urocanic aciduria presenting with mental retardation and intermittent ataxia. Both mutations cannot produce a fully functional enzyme, L70P substitution implies the disruption of an alpha-helix in the N-terminus, which alters its properties and therefore, its function. The R450C change renders impossible any interaction between urocanase and its substrate and loses its enzyme activity

705076

additional information

2 entries