4.2.1.49: urocanate hydratase
This is an abbreviated version!
For detailed information about urocanate hydratase, go to the full flat file.
Word Map on EC 4.2.1.49
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4.2.1.49
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putida
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histidase
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photoactivation
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l-histidine
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histidine-pyruvate
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formiminoglutamate
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medicine
- 4.2.1.49
- putida
- histidase
- photoactivation
- l-histidine
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histidine-pyruvate
- formiminoglutamate
- medicine
Reaction
Synonyms
4'-Imidazolone-5'-propionate hydro-lyase, 4,5-dihydro-4-oxo-5-imidazole-propanoate hydro-lyase, 4-Imidazolone-5'-propionate hydrolyase, HutU, Hydratase, urocanate, Imidazolonepropionate hydrolase, UROC1, Urocanase
ECTree
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General Information
General Information on EC 4.2.1.49 - urocanate hydratase
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malfunction
metabolism
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L70P and R450C mutations in the coding region of the UROC1 gene in a girl with urocanic aciduria presenting with mental retardation and intermittent ataxia. Both mutations cannot produce a fully functional enzyme, L70P substitution implies the disruption of an alpha-helix in the N-terminus, which alters its properties and therefore, its function. The R450C change renders impossible any interaction between urocanase and its substrate and loses its enzyme activity
malfunction
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L-His uptake triggers biofilms efficiently in wild-type Acinetobacter baumannii, but no effect is observed in urocanase and OmpA mutants, while a slight increase is observed in a CarO-deficient strain
malfunction
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L-His uptake triggers biofilms efficiently in wild-type Acinetobacter baumannii, but no effect is observed in urocanase and OmpA mutants, while a slight increase is observed in a CarO-deficient strain
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urocanase plays a central functional role in metabolism of histidine. The histidine degradation pathway occurs via urocanase and leads to the production of purines and pyrimidines
metabolism
the enzyme is involved in histidine degradation and is essential for the catabolic conversion of urocanate to 4-imidazolone-5-propionate, which finally yields glutamate and further glutamine and tricarboxylic acid cycle intemediates such as 2-oxo-pentanedioate
metabolism
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the enzyme is involved in histidine degradation and is essential for the catabolic conversion of urocanate to 4-imidazolone-5-propionate, which finally yields glutamate and further glutamine and tricarboxylic acid cycle intemediates such as 2-oxo-pentanedioate
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metabolism
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urocanase plays a central functional role in metabolism of histidine. The histidine degradation pathway occurs via urocanase and leads to the production of purines and pyrimidines
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