4.2.1.143: versicolorin B synthase
This is an abbreviated version!
For detailed information about versicolorin B synthase, go to the full flat file.
Word Map on EC 4.2.1.143
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4.2.1.143
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aflatoxin
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aspergillus
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hemiacetal
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parasiticus
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mycotoxin
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cyclization
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racemic
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coumarins
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flavoenzymes
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polyketide
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adp-binding
- 4.2.1.143
- aflatoxin
- aspergillus
- hemiacetal
- parasiticus
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mycotoxin
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cyclization
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racemic
- coumarins
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flavoenzymes
- polyketide
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adp-binding
Reaction
Synonyms
aflK, OAVN cyclase, VBS, versicolorin B synthase
ECTree
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General Information
General Information on EC 4.2.1.143 - versicolorin B synthase
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malfunction
metabolism
physiological function
conidiation phenotype and sclerotial phenotype of wild-type, enzyme deletion DELTAaflK, and complemented mutant DELTA aflK::aflK strains, overview. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection
malfunction
Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
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conidiation phenotype and sclerotial phenotype of wild-type, enzyme deletion DELTAaflK, and complemented mutant DELTA aflK::aflK strains, overview. The aflK deletion-mutant DELTAaflK exhibits a significant decrease in sclerotial production and aflatoxin biosynthesis compared with wild-type and the complementation strain DELTAaflK::aflK. The mutation DELTAaflK does not affect the ability of Aspergillus flavus to infect seeds, but downregulates aflatoxin production after seed infection
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genes aflD, aflK, aflQ, and aflR are involved in aflatoxin biosynthesis
metabolism
Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
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genes aflD, aflK, aflQ, and aflR are involved in aflatoxin biosynthesis
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enzyme catalyzes bisfuran ring closure in versiconal hemiacetal to form versicolorin B. This reaction is required for the subsequent activation to aflatoxin B1-8,9 epoxide, a highly reactive and toxic aflatoxin metabolite
physiological function
enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour
physiological function
the enzyme is encoded by gene alfK, which is part of the gene cluster involved in aflatoxin biosynthesis. Negative role of aflK in sclerotial production. Relationship between enzyme AflK and sclerotial production in Aspergillus flavus
physiological function
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enzyme is involved in aflatoxin biosynthesis. A deletion mutant accumulates large amounts of 5'-oxoaverantin, 5'-hydroxyaverantin, averantin, (2'S,5'S)-averufin, and averufanin in the mycelium, leading to bright orange colour
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physiological function
Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
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the enzyme is encoded by gene alfK, which is part of the gene cluster involved in aflatoxin biosynthesis. Negative role of aflK in sclerotial production. Relationship between enzyme AflK and sclerotial production in Aspergillus flavus
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