4.2.1.143: versicolorin B synthase
This is an abbreviated version!
For detailed information about versicolorin B synthase, go to the full flat file.
Word Map on EC 4.2.1.143
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4.2.1.143
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aflatoxin
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aspergillus
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hemiacetal
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parasiticus
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mycotoxin
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cyclization
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racemic
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coumarins
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flavoenzymes
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polyketide
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adp-binding
- 4.2.1.143
- aflatoxin
- aspergillus
- hemiacetal
- parasiticus
-
mycotoxin
-
cyclization
-
racemic
- coumarins
-
flavoenzymes
- polyketide
-
adp-binding
Reaction
Synonyms
aflK, OAVN cyclase, VBS, versicolorin B synthase
ECTree
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Expression
Expression on EC 4.2.1.143 - versicolorin B synthase
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thiabendazole, 4-hydroxy-7-methoxy-3-phenylcoumarin, 4-hydroxy-6,7-dimethylcoumarin, 6,7-dimethoxycoumarin, 4-(bromomethyl)-6,7-dimethoxycoumarin, and 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one show potent antifungal and antiaflatoxigenic activities against Aspergillus flavus. Inhibitory mode of antiaflatoxigenic action by 4-hydroxy-7-methyl-3-phenyl coumarin is based on the downregulation of aflD, aflK, aflQ, and aflR in aflatoxin biosynthesis. The inhibitory mode of antiaflatoxigenic action by 2,3-dihydrobenzofuran is based on the inhibition of the transcription factor (aflS) in the aflatoxin biosynthesis pathway. Complete inhibition of growth at 1 mg/ml
thiabendazole, 4-hydroxy-7-methoxy-3-phenylcoumarin, 4-hydroxy-6,7-dimethylcoumarin, 6,7-dimethoxycoumarin, 4-(bromomethyl)-6,7-dimethoxycoumarin, and 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one show potent antifungal and antiaflatoxigenic activities against Aspergillus flavus. Inhibitory mode of antiaflatoxigenic action by 4-hydroxy-7-methyl-3-phenyl coumarin is based on the downregulation of aflD, aflK, aflQ, and aflR in aflatoxin biosynthesis. The inhibitory mode of antiaflatoxigenic action by 2,3-dihydrobenzofuran is based on the inhibition of the transcription factor (aflS) in the aflatoxin biosynthesis pathway. Complete inhibition of growth at 1 mg/ml
thiabendazole, 4-hydroxy-7-methoxy-3-phenylcoumarin, 4-hydroxy-6,7-dimethylcoumarin, 6,7-dimethoxycoumarin, 4-(bromomethyl)-6,7-dimethoxycoumarin, and 1-(2-methylpiperidin-1-yl)-3-phenylprop-2-en-1-one show potent antifungal and antiaflatoxigenic activities against Aspergillus flavus. Inhibitory mode of antiaflatoxigenic action by 4-hydroxy-7-methyl-3-phenyl coumarin is based on the downregulation of aflD, aflK, aflQ, and aflR in aflatoxin biosynthesis. The inhibitory mode of antiaflatoxigenic action by 2,3-dihydrobenzofuran is based on the inhibition of the transcription factor (aflS) in the aflatoxin biosynthesis pathway. Complete inhibition of growth at 1 mg/ml
Aspergillus flavus ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167
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