4.2.1.141: 2-dehydro-3-deoxy-D-arabinonate dehydratase
This is an abbreviated version!
For detailed information about 2-dehydro-3-deoxy-D-arabinonate dehydratase, go to the full flat file.
Reaction
Synonyms
2-keto-3-deoxyarabinoate/xylonate dehydratase, D-KDA dehydratase, KdaD, KDXD, KDXD/KDAD, saci_1939, Sso3118
ECTree
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Metals Ions
Metals Ions on EC 4.2.1.141 - 2-dehydro-3-deoxy-D-arabinonate dehydratase
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additional information
crystal structures of complexes of the enzyme with magnesium or calcium ions and either a substrate analog 2-oxobutyrate, or the aldehyde enzyme product 2,5-dioxopentanoate reveal the divalent metal ion in the active site is coordinated octahedrally by three conserved carboxylate residues, a water molecule, and both the carboxylate and the oxo groups of the substrate molecule
additional information
multiple sequence alignment analysis of the enzyme indicates the presence of a metal binding site consisting of Glu143, Glu145, and Asp164, which may implicate a metal dependent activity