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Literature summary for 4.2.1.141 extracted from

  • Brouns, S.J.; Barends, T.R.; Worm, P.; Akerboom, J.; Turnbull, A.P.; Salmon, L.; van der Oost, J.
    Structural insight into substrate binding and catalysis of a novel 2-keto-3-deoxy-D-arabinonate dehydratase illustrates common mechanistic features of the FAH superfamily (2008), J. Mol. Biol., 379, 357-371.
    View publication on PubMed
Search for more literature for 4.2.1.141

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of complexes of the enzyme with magnesium or calcium ions and either a substrate analog 2-oxobutyrate, or the aldehyde enzyme product 2,5-dioxopentanoate, 2.1 A resolution Saccharolobus solfataricus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information crystal structures of complexes of the enzyme with magnesium or calcium ions and either a substrate analog 2-oxobutyrate, or the aldehyde enzyme product 2,5-dioxopentanoate reveal the divalent metal ion in the active site is coordinated octahedrally by three conserved carboxylate residues, a water molecule, and both the carboxylate and the oxo groups of the substrate molecule Saccharolobus solfataricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-dehydro-3-deoxy-D-arabinonate Saccharolobus solfataricus key enzyme in degradation of D-arabinose 2,5-dioxopentanoate + H2O
-
 ?
2-dehydro-3-deoxy-D-arabinonate Saccharolobus solfataricus P2 key enzyme in degradation of D-arabinose 2,5-dioxopentanoate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97UA0
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-
Saccharolobus solfataricus P2 Q97UA0
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-dehydro-3-deoxy-D-arabinonate
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 Saccharolobus solfataricus 2,5-dioxopentanoate + H2O
-
 ?
2-dehydro-3-deoxy-D-arabinonate key enzyme in degradation of D-arabinose Saccharolobus solfataricus 2,5-dioxopentanoate + H2O
-
 ?
2-dehydro-3-deoxy-D-arabinonate
-
 Saccharolobus solfataricus P2 2,5-dioxopentanoate + H2O
-
 ?
2-dehydro-3-deoxy-D-arabinonate key enzyme in degradation of D-arabinose Saccharolobus solfataricus P2 2,5-dioxopentanoate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
D-KDA dehydratase
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 Saccharolobus solfataricus
KdaD
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 Saccharolobus solfataricus
Sso3118
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 Saccharolobus solfataricus