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4.2.1.127: linalool dehydratase

This is an abbreviated version!
For detailed information about linalool dehydratase, go to the full flat file.

Word Map on EC 4.2.1.127

Reaction

(3S)-linalool
=
myrcene
 +
H2O

Synonyms

bifunctional linalool dehydratase isomerase, LDI, ldi/LDI, linalool dehydratase isomerase, linalool dehydratase-isomerase, linalool dehydratase/isomerase, LinD, LIS, More

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.127 linalool dehydratase

Inhibitors

Inhibitors on EC 4.2.1.127 - linalool dehydratase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KCl
high salt concentrations (NaCl, KCl, or MgCl2 at a concentration of 220 mM) inhibit the enzyme activity completely
linalyl amine
the simultaneous utilization of 10 mM (3S)-linalool and varying concentrations (0.01-10 mM) of linalyl amine in biotransformations results in almost complete inactixadvation (over 98%) of LinD even when the amine concentration is low
MgCl2
high salt concentrations (NaCl, KCl, or MgCl2 at a concentration of 220 mM) inhibit the enzyme activity completely
NaCl
high salt concentrations (NaCl, KCl, or MgCl2 at a concentration of 220 mM) inhibit the enzyme activity completely
O2
the enzyme requires dithiothreitol as a reducing agent and an oxygen free microenvironment (less than 1% (v/v)) for the dehydration of linalool
pyridoxal 5'-phosphate
1 mM; 35% inhibition
S-adenosyl-L-methionine
40 mM, 80% inhibition
Ti(III)citrate
1 mM, complete inhibition
Urea
20% activity remains at 3 M urea, and no activity is detected in 6 M urea
additional information
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