4.2.1.120: 4-hydroxybutanoyl-CoA dehydratase
This is an abbreviated version!
For detailed information about 4-hydroxybutanoyl-CoA dehydratase, go to the full flat file.
Word Map on EC 4.2.1.120
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4.2.1.120
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crotonyl-coa
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aminobutyricum
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4-hydroxybutyrate
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succinyl-coa
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3-hydroxypropionate/4-hydroxybutyrate
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2-hydroxyacyl-coa
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sedula
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metallosphaera
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chemolithoautotrophic
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non-redox
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thermoproteales
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ignicoccus
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autotrophy
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thermoproteus
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kluyveri
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hospitalis
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neutrophilus
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sulfolobales
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dicarboxylate/4-hydroxybutyrate
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hexacyanoferrateiii
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ketyl
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crenarchaeota
- 4.2.1.120
- crotonyl-coa
- aminobutyricum
- 4-hydroxybutyrate
- succinyl-coa
-
3-hydroxypropionate/4-hydroxybutyrate
-
2-hydroxyacyl-coa
- sedula
- metallosphaera
-
chemolithoautotrophic
-
non-redox
- thermoproteales
-
ignicoccus
-
autotrophy
-
thermoproteus
- kluyveri
- hospitalis
- neutrophilus
- sulfolobales
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dicarboxylate/4-hydroxybutyrate
-
hexacyanoferrateiii
-
ketyl
- crenarchaeota
Reaction
Synonyms
4-hydroxybutyryl-CoA dehydratase, 4-hydroxybutyryl-coenzyme A dehydratase, 4HBD, AbfD, Igni_0595, Msed_1321, Tneu_0422
ECTree
4.2.1.120 4-hydroxybutanoyl-CoA dehydrataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 4.2.1.120 - 4-hydroxybutanoyl-CoA dehydratase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-aminobutyryl-CoA
? + H2O
the natural substrate is 4-aminobutyrate
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-
r
4-hydroxybutanoyl-CoA
(E)-but-2-enoyl-CoA + H2O
-
i.e. crotonyl-CoA
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?
4-hydroxybutanoyl-CoA
(E)-but-2-enoyl-CoA + H2O
the enzyme is part of autotrophic CO2 fixation pathway in archaea
i.e. crotonyl-CoA
-
?
4-hydroxybutanoyl-CoA
(E)-but-2-enoyl-CoA + H2O
-
i.e. crotonyl-CoA
-
?
4-hydroxybutanoyl-CoA
(E)-but-2-enoyl-CoA + H2O
the enzyme is part of autotrophic CO2 fixation pathway in archaea
i.e. crotonyl-CoA
-
?
4-hydroxybutanoyl-CoA
but-3-enoyl-CoA + H2O
-
reaction involves cleavage of an unactivated C-H bond at the beta-carbon
-
-
r
4-hydroxybutanoyl-CoA
but-3-enoyl-CoA + H2O
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selective removal of the (2Re)-hydrogen atom. The stereochemical course at C2 and C3 can be described as anti elimination of the two hydrogen atoms, which is identical to that of acyl-CoA dehydrogenases. The formation of the methyl group of crotonyl-CoA from the hydroxymethyl group of 4-hydroxybutanoyl-CoA occurs with retention of configuration
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-
?
4-hydroxybutanoyl-CoA
crotonyl-CoA + H2O
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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-
?
4-hydroxybutanoyl-CoA
crotonyl-CoA + H2O
the enzyme is involved in the 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
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-
?
additional information
?
-
-
no substrate: cyclopropylcarboxyl-CoA
-
-
?
additional information
?
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4-hydroxybutyryl-CoA dehydratase (4HBD) from Clostridium aminobutyricum catalyzes the reversible dehydration of 4-hydroxybutyryl-CoA to crotonyl-CoA and the irreversible isomerization of vinylacetyl-CoA to crotonyl-CoA. Specific activity of enzyme 4HBD is measured anaerobically in a coupled assay based on determining the amount of crotonyl-CoA formed by beta-oxidation to acetyl-CoA
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-
?
additional information
?
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-
enzyme has an intrinsic vinylacetyl-CoA isomerase activity
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-
?
