Literature summary for 4.2.1.120 extracted from

Friedrich, P.; Darley, D.J.; Golding, B.T.; Buckel, W.
The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme A (2008), Angew. Chem., 47, 3254-3257.

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Organism

Organism	UniProt	Comment	Textmining
Clostridium aminobutyricum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-hydroxybutanoyl-CoA	selective removal of the (2Re)-hydrogen atom. The stereochemical course at C2 and C3 can be described as anti elimination of the two hydrogen atoms, which is identical to that of acyl-CoA dehydrogenases. The formation of the methyl group of crotonyl-CoA from the hydroxymethyl group of 4-hydroxybutanoyl-CoA occurs with retention of configuration	Clostridium aminobutyricum	but-3-enoyl-CoA + H2O	-	?

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Release 2023.1 (January 2023)