4.2.1.100: cyclohexa-1,5-dienecarbonyl-CoA hydratase
This is an abbreviated version!
For detailed information about cyclohexa-1,5-dienecarbonyl-CoA hydratase, go to the full flat file.
Word Map on EC 4.2.1.100
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4.2.1.100
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benzoyl-coa
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aromatica
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thauera
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denitrifying
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rhodopseudomonas
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palustris
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nad+
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atp-driven
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crotonyl-coa
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benzene
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co2
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benzoyl-coenzyme
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two-electron
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anoxic
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ferredoxin
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benzoate
- 4.2.1.100
- benzoyl-coa
- aromatica
-
thauera
-
denitrifying
-
rhodopseudomonas
- palustris
- nad+
-
atp-driven
- crotonyl-coa
- benzene
- co2
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benzoyl-coenzyme
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two-electron
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anoxic
- ferredoxin
- benzoate
Reaction
Synonyms
1,5-dienoyl-CoA hydratase, cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, Cyclohexa-1,5-diene-1-carboxyl-CoA hydratase, DCH, dienoyl-CoA hydratase, EC 4.2.1.102, Ferp_1031
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General Information
General Information on EC 4.2.1.100 - cyclohexa-1,5-dienecarbonyl-CoA hydratase
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metabolism
physiological function
the enzyme is involved in benzoyl-coenzyme A degradation
metabolism
the enzyme is involved in the biodegradation of the environmentally hazardous fluoroaromatics. The 1,5-dienoyl-CoA hydratase (DCH) hydrates the fluoro-1,5-dienoyl-CoA isomers to a mixture of the stable 2-fluoro-6-hydroxy-1-enoyl-CoA and the unstable alpha-fluorohydrin 6-fluoro-6-hydroxy-1-enoyl-CoA. The latter spontaneously decomposes to HF and 6-oxo-cyclohex-1-enoyl-CoA, a common intermediate of the benzoyl-coenzyme A (BzCoA) degradation pathway. 6-Oxo-cyclohex-1-enoyl-CoA hydrolase/hydratase catalyzes the defluorination of 2-fluoro-6-hydroxycyclohex-1-enoyl-CoA to 2-oxo-6-hydroxycyclohex-1-enoyl-CoA and HF again via water addition to an fluorocyclohex-1-enoyl-CoA functionality. Formation of both 3-fluorocyclohexa-1,5-diene-1-carbonyl-CoA and 5-fluorocyclohexa-1,5-diene-1-carbonyl-CoA suggesting a low regioselectivity of benzoyl-coenzyme A (BzCoA) reductase (BCR) for fluorinated BzCoA analogues. Enzyme DCH and bifunctional 6-oxo-cyclohex-1-enoyl-CoA hydrolase (OAH) both initiate defluorination of the 2-fluorocyclohexa-1,5-diene-1-carbonyl-CoA intermediate by 1,4-hydration. Enzyme OAH is competent to hydrate both fluorinated cyclohexa-1,5-diene-carbonyl-CoA isomers and exhibits a similar reactivity as enzyme DCH, and OAH alone is capable of defluorinating both fluorinated cyclohexa-1,5-diene-carbonyl-CoA isomers formed by BCR. Detailed pathway overview
metabolism
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the enzyme is involved in benzoyl-coenzyme A degradation
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metabolism
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the enzyme is involved in the biodegradation of the environmentally hazardous fluoroaromatics. The 1,5-dienoyl-CoA hydratase (DCH) hydrates the fluoro-1,5-dienoyl-CoA isomers to a mixture of the stable 2-fluoro-6-hydroxy-1-enoyl-CoA and the unstable alpha-fluorohydrin 6-fluoro-6-hydroxy-1-enoyl-CoA. The latter spontaneously decomposes to HF and 6-oxo-cyclohex-1-enoyl-CoA, a common intermediate of the benzoyl-coenzyme A (BzCoA) degradation pathway. 6-Oxo-cyclohex-1-enoyl-CoA hydrolase/hydratase catalyzes the defluorination of 2-fluoro-6-hydroxycyclohex-1-enoyl-CoA to 2-oxo-6-hydroxycyclohex-1-enoyl-CoA and HF again via water addition to an fluorocyclohex-1-enoyl-CoA functionality. Formation of both 3-fluorocyclohexa-1,5-diene-1-carbonyl-CoA and 5-fluorocyclohexa-1,5-diene-1-carbonyl-CoA suggesting a low regioselectivity of benzoyl-coenzyme A (BzCoA) reductase (BCR) for fluorinated BzCoA analogues. Enzyme DCH and bifunctional 6-oxo-cyclohex-1-enoyl-CoA hydrolase (OAH) both initiate defluorination of the 2-fluorocyclohexa-1,5-diene-1-carbonyl-CoA intermediate by 1,4-hydration. Enzyme OAH is competent to hydrate both fluorinated cyclohexa-1,5-diene-carbonyl-CoA isomers and exhibits a similar reactivity as enzyme DCH, and OAH alone is capable of defluorinating both fluorinated cyclohexa-1,5-diene-carbonyl-CoA isomers formed by BCR. Detailed pathway overview
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the enzyme is involved in the biodegradation of the environmentally hazardous fluoroaromatics. The 1,5-dienoyl-CoA hydratase (DCH) hydrates the fluorocyclohexa-1,5-diene-1-carbonyl-CoA isomers to a mixture of the stable 2-fluoro-6-hydroxycyclohexa-1-ene-1-carbonyl-CoA and the unstable alpha-fluorohydrin 6-fluoro-6-hydroxycyclohexa-1-ene-1-carbonyl-CoA. The latter spontaneously decomposes to HF and 6-oxo-cyclohexa-1-ene-1-carbonyl-CoA, a common intermediate of the benzoyl-coenzyme A (BzCoA) degradation pathway. 6-Oxo-cyclohexa-1-ene-1-carbonyl-CoA hydrolase/hydratase catalyzes the defluorination of 2-fluoro-6-hydroxy-1-enoyl-CoA to 2-oxo-6-hydroxy-1-enoyl-CoA and HF again via water addition to an fluoro-enoyl-CoA functionality
physiological function
-
the enzyme is involved in the biodegradation of the environmentally hazardous fluoroaromatics. The 1,5-dienoyl-CoA hydratase (DCH) hydrates the fluorocyclohexa-1,5-diene-1-carbonyl-CoA isomers to a mixture of the stable 2-fluoro-6-hydroxycyclohexa-1-ene-1-carbonyl-CoA and the unstable alpha-fluorohydrin 6-fluoro-6-hydroxycyclohexa-1-ene-1-carbonyl-CoA. The latter spontaneously decomposes to HF and 6-oxo-cyclohexa-1-ene-1-carbonyl-CoA, a common intermediate of the benzoyl-coenzyme A (BzCoA) degradation pathway. 6-Oxo-cyclohexa-1-ene-1-carbonyl-CoA hydrolase/hydratase catalyzes the defluorination of 2-fluoro-6-hydroxy-1-enoyl-CoA to 2-oxo-6-hydroxy-1-enoyl-CoA and HF again via water addition to an fluoro-enoyl-CoA functionality
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