4.1.3.42: (4S)-4-hydroxy-2-oxoglutarate aldolase

This is an abbreviated version!
For detailed information about (4S)-4-hydroxy-2-oxoglutarate aldolase, go to the full flat file.

Reaction

Synonyms

2-keto-4-hydroxybutyrate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-keto-4-hydroxyglutaric aldolase, 2-oxo-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 4-hydroxy-2-ketoglutaric aldolase, 4-hydroxy-2-oxoglutarate glyoxylate-lyase, eda, HGA, hydroxyketoglutarate aldolase, Hydroxyketoglutaric aldolase, KHG/KDPG aldolase

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.3 Oxo-acid-lyases

4.1.3.42 (4S)-4-hydroxy-2-oxoglutarate aldolase

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Results	in table
296	AA Sequence
1	Application
2	Cloned(Commentary)
2	General Stability
25	Inhibitors
3	Ki Value [mM]
17	KM Value [mM]
14	Metals/Ions
20	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
20	Organism
4	Pathway
6	pH Optimum
1	pH Range
1	pH Stability
6	Purification (Commentary)
1	Reaction
16	Reference
1	Renatured (Commentary)
1	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
42	Substrates and Products (Substrate)
8	Subunits
13	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

General Stability

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General Stability on EC 4.1.3.42 - (4S)-4-hydroxy-2-oxoglutarate aldolase

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exposure to phosphoric acid at pH 1.6 for 10 min at 4°C causes 95% or greater inactivation. Chloride ion at 50-100 mM or 10 mM 2-oxo-4-hydroxyglutarate markedly decreases both the rate and extent of inactivation; good protection is also afforded by 10 mM pyruvate, glyoxylate, glyoxal, 2-oxoglutarate or 2-oxobutyrate. The inactivation process is characterized by an alteration of secondary and tertiary structure as well as an aggregation to a dimer of the native molecule. Reactivation of enzyme activity to 60-80% of the original level is seen within 20 min at pH 6 to 8

Escherichia coli

721748

irreversibly inactivated by CN- in presence of 4-hydroxy-2-oxoglutarate

Escherichia coli

P0A955

5242