4.1.3.34: citryl-CoA lyase

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For detailed information about citryl-CoA lyase, go to the full flat file.

Reaction

Synonyms

CCL, citryl-CoA lyase, citryl-S-ACP lyase, More, TauO

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.3 Oxo-acid-lyases

                4.1.3.34 citryl-CoA lyase

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Results	in table
3580	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
2	General Information
3	Inhibitors
7	KM Value [mM]
35	Metals/Ions
21	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
31	Organism
7	Pathway
1	pH Optimum
1	pH Range
2	Protein Variants
2	Purification (Commentary)
1	Reaction
1	Reaction Type
19	Reference
3	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
33	Subunits
19	Synonyms
1	Systematic Name
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Engineering

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Engineering on EC 4.1.3.34 - citryl-CoA lyase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D362E

Escherichia coli

-

conversion of citrate synthase, EC 4.1.3.7, into citryl-CoA lyase, EC 4.1.3.34

33348

additional information

Streptomyces griseochromogenes

-

inactivation of the genes of the tautomycetin biosynthetic gene cluster, tauI, tauO, and tauK, which encode for putative P450 oxidase, citryl-CoA lyase, and esterase enzymes, respectively. The mutant STQ0606 (DELTAtauO) does not produce any detectable amount of tautomycetin intermediates but can convert dialkylmaleic anhydride to tautomycetin. Mutant STQ1211 (DELTAtauK) accumulates dialkylmaleic anhydride, whereas the cofermentation of mutant STQ1211 (DELTAtauK) and mutant STQ0606 (DELTAtauO) restores the production of tautomycetin

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