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Literature summary for 4.1.3.34 extracted from
- Functional characterization of the genes tauO, tauK, and tauI in the biosynthesis of tautomycetin (2012), J. Microbiol., 50, 770-776.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene tauO, cloning in Escherichia coli | Streptomyces griseochromogenes |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | inactivation of the genes of the tautomycetin biosynthetic gene cluster, tauI, tauO, and tauK, which encode for putative P450 oxidase, citryl-CoA lyase, and esterase enzymes, respectively. The mutant STQ0606 (DELTAtauO) does not produce any detectable amount of tautomycetin intermediates but can convert dialkylmaleic anhydride to tautomycetin. Mutant STQ1211 (DELTAtauK) accumulates dialkylmaleic anhydride, whereas the cofermentation of mutant STQ1211 (DELTAtauK) and mutant STQ0606 (DELTAtauO) restores the production of tautomycetin | Streptomyces griseochromogenes |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Streptomyces griseochromogenes | the enzyme is involved in the biosynthesis of dialkylmaleic anhydride in Streptomyces griseochromogenes | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces griseochromogenes | - |
gene tauO | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in the biosynthesis of dialkylmaleic anhydride in Streptomyces griseochromogenes | Streptomyces griseochromogenes | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TauO | - |
Streptomyces griseochromogenes |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | inactivation of TauO in the STQ0606 (DELTAtauO) mutant leads to an apramycin-resistant and kanamycin-sensitive phenotype | Streptomyces griseochromogenes |
| metabolism | citryl-CoA lyase has a key function in the biosynthesis of dialkylmaleic anhydride, which is converted to tautomycetin, a dialkylmaleic anhydride antibiotic, tautomycetin biosynthesis overview | Streptomyces griseochromogenes |
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