4.1.1.36: phosphopantothenoylcysteine decarboxylase

This is an abbreviated version!
For detailed information about phosphopantothenoylcysteine decarboxylase, go to the full flat file.

Reaction

Synonyms

4'-Phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase, 4'-phosphopantothenoyl-cysteine decarboxylase, 4'-Phosphopantothenoyl-L-cysteine decarboxylase, 4'-phosphopantothenoylcysteine decarboxylase, 4'-Phosphopantotheoylcysteine decarboxylase, 4�-phosphopantothenoylcysteine decarboxylase, At3g18030, AtHAL3a, Cab3, CoaBC, CoaC, decarboxylase AtHAL3a, Decarboxylase, phosphopantothenoylcysteine, Dfp, dfp flavoprotein, flavoprotein AtHal3a, Hal3, HAL3A, N-((R)-4-phosphopantothenoyl)-L-cysteine carboxy-lyase, NtHAL3, P-PaCysSH decarboxylase, PCC, Phosphopantothenoylcysteine decarboxylase, PPC, PPC decarboxylase, PPC-DC, PPC-decarboxylase, PPCDC

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.36 phosphopantothenoylcysteine decarboxylase

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Results	in table
12	Activating Compound
36339	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
9	Cofactor
3	Crystallization (Commentary)
20	Disease/ Diagnostics
3	General Information
1	IC50 Value
30	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
1	Localization
2	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
41	Organism
1	Oxidation Stability
7	Pathway
14	PDB ID
4	pH Optimum
1	pH Range
3	pI Value
33	Protein Variants
14	Purification (Commentary)
3	Reaction
1	Reaction Type
38	Reference
28	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
8	Subunits
42	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Disease

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Disease on EC 4.1.1.36 - phosphopantothenoylcysteine decarboxylase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Atherosclerosis

A genetic association study of carotid intima-media thickness (CIMT) and plaque in Mexican Americans and European Americans with rheumatoid arthritis.

29482039

Infections

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.

27676316

phosphopantothenoylcysteine decarboxylase deficiency

Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa.

21551303

Pulmonary Disease, Chronic Obstructive

Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1.

19266201

Tuberculosis

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.

33420031

Tuberculosis

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

32206243

Tuberculosis

Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity.

33939919

Tuberculosis

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.

27676316

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