4.1.1.36: phosphopantothenoylcysteine decarboxylase

This is an abbreviated version!
For detailed information about phosphopantothenoylcysteine decarboxylase, go to the full flat file.

Reaction

Synonyms

4'-Phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase, 4'-phosphopantothenoyl-cysteine decarboxylase, 4'-Phosphopantothenoyl-L-cysteine decarboxylase, 4'-phosphopantothenoylcysteine decarboxylase, 4'-Phosphopantotheoylcysteine decarboxylase, 4�-phosphopantothenoylcysteine decarboxylase, At3g18030, AtHAL3a, Cab3, CoaBC, CoaC, decarboxylase AtHAL3a, Decarboxylase, phosphopantothenoylcysteine, Dfp, dfp flavoprotein, flavoprotein AtHal3a, Hal3, HAL3A, N-((R)-4-phosphopantothenoyl)-L-cysteine carboxy-lyase, NtHAL3, P-PaCysSH decarboxylase, PCC, Phosphopantothenoylcysteine decarboxylase, PPC, PPC decarboxylase, PPC-DC, PPC-decarboxylase, PPCDC

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.36 phosphopantothenoylcysteine decarboxylase

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Results	in table
12	Activating Compound
36339	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
9	Cofactor
3	Crystallization (Commentary)
20	Disease/ Diagnostics
3	General Information
1	IC50 Value
30	Inhibitors
1	Ki Value [mM]
6	KM Value [mM]
1	Localization
2	Metals/Ions
9	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
41	Organism
1	Oxidation Stability
7	Pathway
14	PDB ID
4	pH Optimum
1	pH Range
3	pI Value
33	Protein Variants
14	Purification (Commentary)
3	Reaction
1	Reaction Type
38	Reference
28	Source Tissue
5	Specific Activity [micromol/min/mg]
2	Storage Stability
47	Substrates and Products (Substrate)
8	Subunits
42	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.1.1.36 - phosphopantothenoylcysteine decarboxylase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(R)-4'-phospho-N-pantothenoylcysteine

4'-phosphopantetheine + CO2

Escherichia coli

-

-

652126

-

652126

?

(R)-4'-phospho-N-pantothenoylcysteine

pantotheine 4'-phosphate + CO2

Homo sapiens

-

-

664025

-

-

?

alpha-Carboxy-CoA

?

Rattus norvegicus

-

at low rate

4409

-

-

?

D-pantothenoylcysteine

pantotheine + CO2

Arabidopsis thaliana

-

pantothenoylaminoethenethiol is the intermediate in decarboxylation

652261

-

652261

?

Dephospho-alpha-carboxy-CoA

?

Rattus norvegicus

-

at low rate

4409

-

-

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

?

Micrococcus luteus

-

enzyme is involved in coenzyme A biosynthesis

4412

-

-

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

17 entries

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

22 entries

additional information

?

-

2 entries

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Anas platyrhynchos

-

-

4410

-

4410

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Bos taurus

-

-

4408

-

4408

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Equus caballus

-

-

4411

-

4411

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Equus caballus

-

-

4414

-

4414

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Equus caballus

-

-

4416

-

4416

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Equus caballus

-

specific for

4408

-

4408

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Escherichia coli

-

-

4406

-

4406

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Escherichia coli

-

-

4415

-

4415

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Micrococcus luteus

-

-

4412

-

4412

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Morganella morganii

-

-

4406

-

4406

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Oryctolagus cuniculus

-

-

4408

-

4408

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Rattus norvegicus

-

-

4406

-

4406

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Rattus norvegicus

-

-

4407

-

4407

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Rattus norvegicus

-

-

4408

-

4408

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Rattus norvegicus

-

-

4409

-

4409

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Rattus norvegicus

-

-

4413

-

4413

?

N-((R)-4-Phosphopantothenoyl)-L-Cys

Pantotheine 4-phosphate + CO2

Sus scrofa

-

-

4408

-

4408

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

-

-

652261

-

652261

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

Q9SWE5

-

652126

-

652126

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

Q9SWE5

-

652908

-

652908

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

Q9SWE5

-

682401

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

Q9SWE5

-

652908

step in coenzyme A biosynthesis

652908

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

-

key step in coenzyme A biosynthesis

652261

-

652261

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Arabidopsis thaliana

Q9SWE5

key step in coenzyme A biosynthesis

652126

-

652126

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

-

651576

-

651576

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

-

652126

-

652126

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

-

652148

-

652148

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

activity is fused with another enzyme bearing phosphopantothenoylcysteine synthetase activity to form a bifunctional enzyme, CoABC

650566

-

650566

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

biosynthesis of coenzyme A

650566

-

650566

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

key step in coenzyme A biosynthesis

652148

-

652148

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Escherichia coli

-

key step in coenzyme A biosynthestic pathway

652126

-

652126

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Homo sapiens

-

-

649215

-

649215

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Homo sapiens

-

essential enzyme in the biosynthesis of coenzyme A

649215

-

649215

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Methanocaldococcus jannaschii

-

-

674749

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Methanocaldococcus jannaschii DSM 2661

-

-

674749

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Mycobacterium tuberculosis

-

-

677979

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Oryza sativa

-

-

702179

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Oryza sativa

-

the 4’-phosphopantothenoylcysteine decarboxylase activity of HAL3 is not associated with its role in cell division

705844

-

-

?

N-[(R)-4'-phosphopantothenoyl]-L-cysteine

pantotheine 4'-phosphate + CO2

Saccharomyces cerevisiae

-

-

705847

-

-

?

additional information

?

-

Rattus norvegicus

-

pantothenylcysteine is decarboxylated

4407

-

-

?

additional information

?

-

Rattus norvegicus

-

pantothenylcysteine is decarboxylated

4409

-

-

?