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4.1.1.36: phosphopantothenoylcysteine decarboxylase

This is an abbreviated version!
For detailed information about phosphopantothenoylcysteine decarboxylase, go to the full flat file.

Word Map on EC 4.1.1.36

Reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine
=
pantotheine 4'-phosphate
 +
CO2

Synonyms

4'-Phospho-N-(D-pantothenoyl)-L-cysteine carboxy-lyase, 4'-phosphopantothenoyl-cysteine decarboxylase, 4'-Phosphopantothenoyl-L-cysteine decarboxylase, 4'-phosphopantothenoylcysteine decarboxylase, 4'-Phosphopantotheoylcysteine decarboxylase, 4’-phosphopantothenoylcysteine decarboxylase, At3g18030, AtHAL3a, Cab3, CoaBC, CoaC, decarboxylase AtHAL3a, Decarboxylase, phosphopantothenoylcysteine, Dfp, dfp flavoprotein, flavoprotein AtHal3a, Hal3, HAL3A, N-((R)-4-phosphopantothenoyl)-L-cysteine carboxy-lyase, NtHAL3, P-PaCysSH decarboxylase, PCC, Phosphopantothenoylcysteine decarboxylase, PPC, PPC decarboxylase, PPC-DC, PPC-decarboxylase, PPCDC

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.36 phosphopantothenoylcysteine decarboxylase

Engineering

Engineering on EC 4.1.1.36 - phosphopantothenoylcysteine decarboxylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A174S
-
site-directed mutagenesis
A174V
-
site-directed mutagenesis
C175S
D177N
-
site-directed mutagenesis
G179A
-
site-directed mutagenesis
H90N
exchange leads to complete inactivation of the enzyme
R95Q
-
site-directed mutagenesis
A17D
-
site-directed mutagenesis
C158A
-
constructed by sequential polymerase chain reaction
G14S
-
site-directed mutagenesis
G15A
-
site-directed mutagenesis
H90N
-
constructed by sequential polymerase chain reaction
I16L
-
site-directed mutagenesis
K20N
-
site-directed mutagenesis
K20Q
-
site-directed mutagenesis
C54A
-
comparable activity with that of the wild type enzyme
C73A
-
comparable activity with that of the wild type enzyme
C94A
-
comparable activity with that of the wild type enzyme
C96A
-
comparable activity with that of the wild type enzyme
E168A
-
drastically reduced activity
E168D
-
significantly decreased activity
E168K
-
residual activity
H139A/E168K
-
drastically reduced PPC decarboxylase activity
H87A
-
reduced activity
H87N
-
reduced activity
C54A
-
comparable activity with that of the wild type enzyme
-
C73A
-
comparable activity with that of the wild type enzyme
-
C96A
-
comparable activity with that of the wild type enzyme
-
E168D
-
significantly decreased activity
-
E168K
-
residual activity
-
D178N
-
site-directed mutagenesis, Asp 178 is not important for the activity
G180A
-
site-directed mutagenesis, mutant enzyme has a partly reduced activity