3.6.4.B1: kinesin K16

This is an abbreviated version!
For detailed information about kinesin K16, go to the full flat file.

Reaction

Synonyms

AtPAKRP1, AtPAKRP1L, GhKCH1, K16MD, KCBP, KIF 14, KIF18A, KIF4, KIF5, KIF5B, KIF5C, KIFC5A, kinesin K-16, kinesin K16, kinesin K16MD, kinesin KIF17b, kinesin kif5c, kinesin superfamily protein 5B, kinesin-1 motor protein, kinesin-like calmodulin-binding protein, KLP-6 kinesin, MS-KIF18A

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.4 Acting on acid anhydrides to facilitate cellular and subcellular movement

                3.6.4.B1 kinesin K16

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
5	Activating Compound
2	Application
9	Cloned(Commentary)
3	Crystallization (Commentary)
5	Disease/ Diagnostics
2	Inhibitors
18	Localization
2	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
25	Organism
2	pH Optimum
4	Protein Variants
2	Purification (Commentary)
1	Reaction
25	Reference
14	Source Tissue
2	Specific Activity [micromol/min/mg]
18	Substrates and Products (Substrate)
10	Subunits
23	Synonyms
1	Temperature Optimum [°C]

Engineering

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Engineering on EC 3.6.4.B1 - kinesin K16

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Protein Variants Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Q101C

Oryza sativa

-

modification in loop L5 and labeling of mutant Cys residue with 2-(4'-(2''-iodoacetamido)phenyl)aminonaphthalene-6-sulfonic acid. In the absence of nucleotides, label is incorporated at almost equimolar ratio into loop L5. In the presence of ATP and ADP, the incorporated amount is reduced to 0.62 and 0.32 mol label per mol of motor domain, respectively

687438

T93N

Rattus norvegicus

-

rigor-mutant, binds to microtubules but fails to move along them

687916

additional information

2 entries

additional information

Homo sapiens

-

in KIF14 depleted cells, citron kinase but not other components of the central spindle and cleavage furrow fail to localize. Localization of KIF14 and citron kinase to the central spindle and midbody is codependent, they form a complex depending on the activation state of citron kinase

687900

additional information

Mus musculus

-

overexpression of KIFC5A in mouse cells causes the formation of aberrant, non-separated microtubule asters and mitotic arrest in a prometaphase-like state. KIFC5A knockdown partly rescues the phenotype caused by inhibition of plus-end directed motor Eg5 by monastrol on the mitotic spindle. Silencing also results in centrosome amplification detectable throughout the cell cycle. KIFC5A interacts with nucleotide-binding proteins 1 and 2. Knockdown of nucleotide-binding protein 1 or double knockdown of nucleotide-binding proteins 1 and 2 both phenocopy the KIFC5A silencing effect

687910