3.6.1.60: diadenosine hexaphosphate hydrolase (AMP-forming)

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Word Map on EC 3.6.1.60

3.6.1.60

polyphosphates

diphosphoinositol

prostate

autoantibody

nudix

serous

nappa

tumor-associated

dipps

phosphohydrolases

trim39

medicine

Reaction

Synonyms

At3g26690, AtNUDT13, DDP1, diphosphoinositol polyphosphate phosphohydrolase, DIPP, hAps1, hAps2, More, NUDT10, NUDT11

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)

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2	Activating Compound
15	AA Sequence
1	Application
4	Cloned(Commentary)
26	Disease/ Diagnostics
1	Expression
3	General Information
2	IC50 Value
9	Inhibitors
9	kcat/KM [mM/s]
2	Ki Value [mM]
9	KM Value [mM]
2	Localization
9	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
9	Organism
13	PDB ID
7	pH Optimum
2	pH Range
3	Protein Variants
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7	Reaction
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24	Source Tissue
20	Substrates and Products (Substrate)
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11	Synonyms
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4	Temperature Optimum [°C]
9	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.6.1.60 - diadenosine hexaphosphate hydrolase (AMP-forming)

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P1,P5-bis(5'-adenosyl)pentaphosphate + H2O

adenosine 5'-tetraphosphate + AMP

2 entries

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-pentaphosphate + AMP

Homo sapiens

Q8NFP7, Q96G61

marked preference for adenine over guanine nucleotides. The enzyme controls intracellular P1,P5-bis(5'-adenosyl)pentaphosphate and P1,P6-bis(5'-adenosyl)hexaphosphate levels

714610

P1,P6-bis(5'-adenosyl)hexaphosphate + H2O

adenosine 5'-tetraphosphate + ADP

2 entries