3.6.1.60: diadenosine hexaphosphate hydrolase (AMP-forming)

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For detailed information about diadenosine hexaphosphate hydrolase (AMP-forming), go to the full flat file.

Reaction

Synonyms

At3g26690, AtNUDT13, DDP1, diphosphoinositol polyphosphate phosphohydrolase, DIPP, hAps1, hAps2, More, NUDT10, NUDT11

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.60 diadenosine hexaphosphate hydrolase (AMP-forming)

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General Information on EC 3.6.1.60 - diadenosine hexaphosphate hydrolase (AMP-forming)

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Saccharomyces cerevisiae

Q99321

the content of acid-soluble and acid-insoluble polyphosphates under DDP1 overexpression decreases by 9 and 28%, respectively. The average chain length of salt-soluble and alkali-soluble fractions does not change in the overexpressing strain, and that of acid-soluble polyphosphate increases under phosphate excess. At the initial stage of polyphosphate recovery after phosphorus starvation, the chain length of the acid-soluble fraction in transformed cells is lower compared to the recipient strain. In DDP1 deletion mutant, the level of inositol pyrophosphate is twice higher, while the level of polyphosphate is reduced. The overexpression of DDP1 probably leads to a decrease in the level of diphosphoinositol pentakisphosphate and bis(diphosphoinositol) tetrakisphosphate in the cell. These compounds seem to be involved in the regulation of polyphosphate synthesis and degradation

756069

metabolism

Saccharomyces cerevisiae

Q99321

diphosphoinositol polyphosphate phosphohydrolase (DDP1, EC 3.6.1.52) is also a diadenosine hexaphosphate hydrolase (AMP-forming) (EC 3.6.1.60) and shows endopolyphosphatase (EC 3.6.1.10) activity. The relationship between inositol pyrophosphate and polyphosphate metabolisms seems to be complicated

756069

physiological function

Saccharomyces cerevisiae

Q99321

yeast diphosphoinositol polyphosphate phosphohydrolase (DDP1) having endopolyphosphatase activity on inorganic polyphosphate metabolism in Saccharomyces cerevisiae. Complex nature of DDP1 involvement in the regulation of polyphosphate content and chain length in yeasts

756069