3.6.1.43: dolichyldiphosphatase
This is an abbreviated version!
For detailed information about dolichyldiphosphatase, go to the full flat file.
Reaction
Synonyms
acid PPase, acid pyrophosphatase, CAX4, Dol-P-P phosphatase, dol-P-P phosphohydrolase, Dol-PP phosphatase, dolichol diphosphatase, Dolicholpyrophosphatase, dolichyl diphosphate phosphohydrolase, dolichyl pyrophosphatase, dolichyl pyrophosphate phosphatase, dolichyl-diphosphate phosphatase, DPPase
ECTree
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General Information
General Information on EC 3.6.1.43 - dolichyldiphosphatase
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malfunction
metabolism
physiological function
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in enzyme-deficient cells showing endoplasmic reticulum stress, membrane and growth defect, the N-glycosylation of the vacuolar carboxypeptidase is severely affected, and expression of the endoplasmic reticulum chaperone Kar2p is elevated, which results in unfolded protein response activation as an adaptive response
malfunction
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in enzyme-deficient cells showing endoplasmic reticulum stress, membrane and growth defect, the N-glycosylation of the vacuolar carboxypeptidase is severely affected, and expression of the endoplasmic reticulum chaperone Kar2p is elevated, which results in unfolded protein response activation as an adaptive response
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olicholpyrophosphatase participates in glycoprotein biosynthesis
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the enzyme regulates membrane biogenesis by coordinating lipid homeostasis with protein quality control
physiological function
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the enzyme regulates membrane biogenesis by coordinating lipid homeostasis with protein quality control
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