3.5.99.8: 5-nitroanthranilic acid aminohydrolase
This is an abbreviated version!
For detailed information about 5-nitroanthranilic acid aminohydrolase, go to the full flat file.
Reaction
Synonyms
5NAA aminohydrolase, 5NAA deaminase, 5NAA-A, 5NAA-aminohydrolase, NAAA
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Substrates Products
Substrates Products on EC 3.5.99.8 - 5-nitroanthranilic acid aminohydrolase
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REACTION DIAGRAM
5-nitroanthranilate + H2O
5-nitrosalicylate + NH3
initial step in biodegradation of 5-nitroanthranilic acid as sole carbon, nitrogen and energy source
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mechanism of release of the nitro group, overview. The nitro group is spontaneously eliminated as nitrite concomitant with the formation of a lactone from the ring fission product of 5NSA dioxygenation
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additional information
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mechanism of release of the nitro group, overview. The nitro group is spontaneously eliminated as nitrite concomitant with the formation of a lactone from the ring fission product of 5NSA dioxygenation
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additional information
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enzyme 5NAA-A is specific for 5-nitroanthranilate (5NAA) and cannot hydrolyze other tested derivatives, i.e. 4-nitroaniline, 4-amino-3-nitrobenzoic acid, and 2-bromo-5-nitrobenzoic acid, which are likewise poor inhibitors. The enzyme employs a nucleophilic aromatic substitution mechanism
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