3.5.4.38: single-stranded DNA cytosine deaminase

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For detailed information about single-stranded DNA cytosine deaminase, go to the full flat file.

Word Map on EC 3.5.4.38

3.5.4.38

apobec3s

deamination

hypermutation

deaminases

immunoglobulin

uracil

viruses

apolipoprotein

retroviruses

diversification

ige

virion

polypeptide-like

retroviral

mrna-editing

retrotransposons

antiretroviral

retroelements

vif-deficient

anti-hiv-1

retrotransposition

class-switching

glycosylase

lentiviruses

uracil-dna

line-1

proviral

vif-mediated

aid-dependent

cccdna

aid-induced

abasic

c-to-u

encapsidation

translesion

r-loops

sivmac

molecular biology

samhd1

medicine

Reaction

Synonyms

A3F, activation-induced cytidine deaminase, activation-induced deaminase, AICDA, AID, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G, APOBEC3H, APOBEC3Z1, CDA1, single-stranded (ss)DNA deoxycytidine deaminase, ssDNA cytidine deaminase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.38 single-stranded DNA cytosine deaminase

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Results	in table
1	Activating Compound
179	AA Sequence
2	Application
15	Cloned(Commentary)
8	Crystallization (Commentary)
1237	Disease/ Diagnostics
3	Expression
28	General Information
1	General Stability
4	Inhibitors
1	KM Value [mM]
8	Localization
2	Metals/Ions
9	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
61	Organism
35	PDB ID
11	pH Optimum
1	pH Range
8	Posttranslational Modification
29	Protein Variants
13	Purification (Commentary)
1	Reaction
47	Reference
30	Source Tissue
59	Substrates and Products (Substrate)
11	Subunits
93	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

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Application on EC 3.5.4.38 - single-stranded DNA cytosine deaminase

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medicine

Homo sapiens

Q9HC16

APOBEC3G mediated checkpoint activation through checkpoint kinase 2 (Chk2) is one of the critical regulatory mechanisms that underlies the preferential DNA damage checkpoint response and radioresistance of Glioma Initiating Cells. Thus, anti-APOBEC3G therapy may synergize with radiotherapy and other current treatments to overcome the therapeutic resistance of gliomas. APOBEC3G represents a potential molecular target for novel therapeutics that will improve the treatment outcome of glioma patients

757890

molecular biology

Petromyzon marinus

a target-AID base editor, designed to recruit cytidine deaminase (CDA) to the target DNA locus via the CRISPR/Cas9 system, can directly induce C to T mutation without double-strand breaks and donor DNA. This system is adopted in Yarrowia lipolytica for multiplex gene disruption. Target-specific gRNA(s) and a fusion protein consisting of a nickase Cas9, CDA1, and uracil DNA glycosylase inhibitor are expressed from a single plasmid to disrupt target genes by introducing a stop codon via C to T mutation within the mutational window. Using this Target-AID system, single gene disruption and simultaneous double gene disruption are achieved with the efficiencies up to 94% and 31%, respectively

753049